N-(pyrrolidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide

Base Information

• Chemical Name: N-(pyrrolidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide
• CAS No.: 1240996-82-0
• Molecular Formula: C₂₁H₁₈Cl₂N₄O₂
• Molecular Weight: 429.306
• Mol file: 1240996-82-0.mol

Synonyms:N-(pyrrolidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide

Chemical Property of N-(pyrrolidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(pyrrolidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide

There total 6 articles about N-(pyrrolidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-0c]pyrazole-3-carboxylic acid (1240998-70-2) + 1-aminopyrrolidine hydrochloride (63234-71-9) → N-(pyrrolidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide (1240996-82-0)

Guidance literature:

1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-0c]pyrazole-3-carboxylic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 1h;

1-aminopyrrolidine hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 22h;

DOI:10.1016/j.ejmech.2014.05.055

Reference yield: 94.0%

→ N-(pyrrolidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide (1240996-82-0)

Guidance literature:

Reference yield:

ethyl 2-(3-hydroxy-6-methylbenzofuran-2-yl)-2-oxoacetate (1240996-29-5) → N-(pyrrolidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide (1240996-82-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ethanol / 1.5 h / Reflux

2.1: toluene-4-sulfonic acid / toluene / 30 h / Reflux

3.1: potassium hydroxide / ethanol; water / 1 h / 80 °C

4.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 1 h / 20 °C

4.2: 22 h / 20 °C

With benzotriazol-1-ol; toluene-4-sulfonic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; potassium hydroxide; In ethanol; dichloromethane; water; toluene;

DOI:10.1016/j.ejmech.2014.05.055

upstream raw materials:

ethyl 2-(3-hydroxy-6-methylbenzofuran-2-yl)-2-oxoacetate

ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-2-(6-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl)acetate

ethyl ester of 1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carboxylic acid

1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-0c]pyrazole-3-carboxylic acid