ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-2-(6-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl)acetate

Base Information

• Chemical Name: ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-2-(6-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl)acetate
• CAS No.: 1618102-62-7
• Molecular Formula: C₁₉H₁₆Cl₂N₂O₄
• Molecular Weight: 407.253
• Mol file: 1618102-62-7.mol

Synonyms:ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-2-(6-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl)acetate

Chemical Property of ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-2-(6-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-2-(6-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl)acetate

There total 2 articles about ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-2-(6-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ethyl 2-(3-hydroxy-6-methylbenzofuran-2-yl)-2-oxoacetate (1240996-29-5) + 2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) → ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-2-(6-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl)acetate (1618102-62-7)

Guidance literature:

In ethanol; for 1.5h; Reflux;

DOI:10.1016/j.ejmech.2014.05.055

Reference yield:

6-methylbenzofuran-3(2H)-one (20895-41-4) → ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-2-(6-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl)acetate (1618102-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium / ethanol / 20 h / 20 °C / Inert atmosphere

2: ethanol / 1.5 h / Reflux

With sodium; In ethanol;

DOI:10.1016/j.ejmech.2014.05.055

Reference yield: 52.0%

ethyl 2-(2-(2,4-dichlorophenyl)hydrazono)-2-(6-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl)acetate (1618102-62-7) → ethyl ester of 1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carboxylic acid (1240996-28-4)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 30h; Reflux;

DOI:10.1016/j.ejmech.2014.05.055

upstream raw materials:

ethyl 2-(3-hydroxy-6-methylbenzofuran-2-yl)-2-oxoacetate

2,4-dichlorophenyl hydrazine hydrochloride

6-methylbenzofuran-3(2H)-one

Downstream raw materials:

ethyl ester of 1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carboxylic acid

1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-0c]pyrazole-3-carboxylic acid

N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide

N-(pyrrolidin-1-yl)-1-(2,4-dichlorophenyl)-6-methyl-1H-benzofuro[3,2-c]pyrazole-3-carbohydrazide