2,2,2-trifluoro-N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)acetamide
CAS No.:881678-46-2
Molecular Formula:C₂₀H₁₇F₃N₂O₃S
Molecular Weight:422.428
Hs Code.:

Synonyms:2,2,2-trifluoro-N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)acetamide

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Chemical Property of 2,2,2-trifluoro-N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)acetamide

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Technology Process of 2,2,2-trifluoro-N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)acetamide

There total 6 articles about 2,2,2-trifluoro-N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)-1,1-diphenylmethanamine

: 407-25-0
trifluoroacetic anhydride

: 881678-46-2
2,2,2-trifluoro-N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)acetamide

Guidance literature:: N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)-1,1-diphenylmethanamine; With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 10 - 35 ℃; for 3h;

trifluoroacetic anhydride; With triethylamine; In tetrahydrofuran; at 0 - 35 ℃; for 0.5h;

Reference yield: 100.0%

: N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)-1,1-diphenylmethanamine

: 358-23-6
trifluoromethylsulfonic anhydride

: 881678-46-2
2,2,2-trifluoro-N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)acetamide

Guidance literature:: N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)-1,1-diphenylmethanamine; With hydrogenchloride; methanol; hydrogen; palladium 10% on activated carbon; In water; ethyl acetate; at 20 ℃; for 3h;

trifluoromethylsulfonic anhydride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

: 881673-31-0
1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde

: 881678-46-2
2,2,2-trifluoro-N-({1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 6 h / 10 - 35 °C / Molecular sieve

1.2: 3 h / 10 - 35 °C / Molecular sieve

2.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 10 - 35 °C

2.2: 0.5 h / 0 - 35 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; ethyl acetate;