1,2-DIHYDRO-4-(METHOXYMETHYL)-6-METHYL-5-NITRO-2-OXONICOTINONITRILE

Base Information

• Chemical Name: 1,2-DIHYDRO-4-(METHOXYMETHYL)-6-METHYL-5-NITRO-2-OXONICOTINONITRILE
• CAS No.: 6281-75-0
• Molecular Formula: C₉H₉N₃O₄
• Molecular Weight: 223.188
• Mol file: 6281-75-0.mol

Synonyms:Nicotinonitrile,1,2-dihydro-4-(methoxymethyl)-6-methyl-5-nitro-2-oxo- (7CI); Nicotinonitrile,2-hydroxy-4-(methoxymethyl)-6-methyl-5-nitro- (6CI,8CI);2-Methyl-3-nitro-4-methoxymethyl-5-cyano-6-hydroxypyridine; NSC 5867

Chemical Property of 1,2-DIHYDRO-4-(METHOXYMETHYL)-6-METHYL-5-NITRO-2-OXONICOTINONITRILE

Chemical Property:

• PSA: 111.70000
• LogP: 1.13278

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxy-4-(methoxymethyl)-6-methylnicotinonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-DIHYDRO-4-(METHOXYMETHYL)-6-METHYL-5-NITRO-2-OXONICOTINONITRILE

There total 4 articles about 1,2-DIHYDRO-4-(METHOXYMETHYL)-6-METHYL-5-NITRO-2-OXONICOTINONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

6-methyl-4-[(methyloxy)methyl]-2-oxo-1,2-dihydro-3-pyridinecarbonitrile (6339-38-4) → 4-(methoxymethyl)-6-methyl-5-nitro-2-oxo-1,2-dihydropyridine-3-carbonitrile (6281-75-0)

Guidance literature:

With nitric acid; acetic anhydride;

DOI:10.1016/j.molstruc.2010.01.038

Reference yield:

2-hydroxy-4-methoxymethyl-6-methyl-nicotinonitrile (6339-38-4) → 2-hydroxy-4-methoxymethyl-6-methyl-5-nitro-nicotinonitrile (6281-75-0)

Guidance literature:

With nitric acid; acetic anhydride;

DOI:10.1021/ja01240a026 DOI:10.1246/bcsj.19.1

Reference yield:

1-methoxypentane-2,4-dione (6290-50-2) → 2-hydroxy-4-methoxymethyl-6-methyl-5-nitro-nicotinonitrile (6281-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; piperidine

2: acetic acid anhydride; fuming HNO₃

With piperidine; ethanol; nitric acid; acetic anhydride;

DOI:10.1021/ja01240a026 DOI:10.1246/bcsj.19.1

upstream raw materials:

2-hydroxy-4-methoxymethyl-6-methyl-nicotinonitrile

1-methoxypentane-2,4-dione

6-methyl-4-[(methyloxy)methyl]-2-oxo-1,2-dihydro-3-pyridinecarbonitrile

Downstream raw materials:

2-chloro-4-(methoxymethyl)-6-methyl-5-nitropyridine-3-carbonitrile

5-amino-2-chloro-4-methoxymethyl-6-methyl-nicotinonitrile

3-amino-5-aminomethyl-4-methoxymethyl-2-methylpyridine

Refernces

• 1、 Gavrilov et al.. "-". . . Retrieved 1976.