2-Methyl-3-amino-4-methoxymethyl-5-aminomethylpyridine

Base Information

• Chemical Name: 2-Methyl-3-amino-4-methoxymethyl-5-aminomethylpyridine
• CAS No.: 35623-09-7
• Molecular Formula: C₉H₁₅N₃O
• Molecular Weight: 181.238
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40189101
• Wikidata: Q83061037
• ChEMBL ID: CHEMBL1620949
• Mol file: 35623-09-7.mol

Synonyms:35623-09-7;2-Methyl-3-amino-4-methoxymethyl-5-aminomethylpyridine;5-amino-4-(methoxymethyl)-6-methyl-3-pyridinemethanamine;5-(aminomethyl)-4-(methoxymethyl)-2-methylpyridin-3-amine;Oprea1_123356;Oprea1_326399;CBDivE_012961;CHEMBL1620949;DTXSID40189101;HMS1684L09;STL553774;AKOS000560073;SDCCGMLS-0022051.P002

Chemical Property of 2-Methyl-3-amino-4-methoxymethyl-5-aminomethylpyridine

Chemical Property:

• Vapor Pressure: 6.32E-05mmHg at 25°C
• Boiling Point: 345.1°Cat760mmHg
• Flash Point: 162.5°C
• PSA: 74.16000
• Density: 1.13g/cm³
• LogP: 1.85880
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 181.121512110
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=C(C(=C1N)COC)CN

Technology Process of 2-Methyl-3-amino-4-methoxymethyl-5-aminomethylpyridine

There total 5 articles about 2-Methyl-3-amino-4-methoxymethyl-5-aminomethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-(methoxymethyl)-6-methyl-5-nitropyridine-3-carbonitrile (719-48-2) → 3-amino-5-aminomethyl-4-methoxymethyl-2-methylpyridine (35623-09-7)

Guidance literature:

With palladium on activated charcoal; ethanol; platinum; Hydrogenation;

DOI:10.1021/ja01240a026 DOI:10.1246/bcsj.19.1

Reference yield:

2-hydroxy-4-methoxymethyl-6-methyl-5-nitro-nicotinonitrile (6281-75-0) → 3-amino-5-aminomethyl-4-methoxymethyl-2-methylpyridine (35623-09-7)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃; PCl₅

2: palladium; aqueous methanol. HCl / Hydrogenation

With hydrogenchloride; phosphorus pentachloride; palladium; trichlorophosphate;

Reference yield:

2-hydroxy-4-methoxymethyl-6-methyl-nicotinonitrile (6339-38-4) → 3-amino-5-aminomethyl-4-methoxymethyl-2-methylpyridine (35623-09-7)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid anhydride; fuming HNO₃

2: chlorobenzene; PCl₅

3: platinum; palladium/charcoal; ethanol / Hydrogenation

With palladium on activated charcoal; ethanol; phosphorus pentachloride; nitric acid; acetic anhydride; chlorobenzene; platinum;

DOI:10.1246/bcsj.19.1

upstream raw materials:

2-chloro-4-(methoxymethyl)-6-methyl-5-nitropyridine-3-carbonitrile

2-hydroxy-4-methoxymethyl-6-methyl-nicotinonitrile

1-methoxypentane-2,4-dione

2-hydroxy-4-methoxymethyl-6-methyl-5-nitro-nicotinonitrile