Methyl 3-chloro-4,6-dimethoxy-2-methylbenzoate

Base Information

Chemical Name:Methyl 3-chloro-4,6-dimethoxy-2-methylbenzoate
CAS No.:950-82-3
Molecular Formula:C₁₁H₁₃ClO₄
Molecular Weight:244.675
Hs Code.:
DSSTox Substance ID:DTXSID101246424

Synonyms:methyl 3-chloro-4,6-dimethoxy-2-methylbenzoate;950-82-3;DTXSID101246424

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-chloro-4,6-dimethoxy-2-methylbenzoate

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:244.0502366
Heavy Atom Count:16
Complexity:246

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=CC(=C1Cl)OC)OC)C(=O)OC

Technology Process of Methyl 3-chloro-4,6-dimethoxy-2-methylbenzoate

There total 6 articles about Methyl 3-chloro-4,6-dimethoxy-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 6110-37-8
methyl 2,4-dimethoxy-6-methylbenzoate

: 950-82-3
methyl 3-chloro-4,6-dimethoxy-2-methylbenzoate

Guidance literature:: With sulfuryl dichloride; In diethyl ether; for 4h; Reflux;
DOI:10.1021/acs.jmedchem.6b01301

Reference yield:

: 58106-55-1
2,4-dihydroxy-3-bromo-6-methyl-benzoic acid methyl ester

: 950-82-3
methyl 3-chloro-4,6-dimethoxy-2-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / SO₂Cl₂ / diethyl ether / 3.5 h / Ambient temperature

2: 1.41 g / K₂CO₃ / acetone / 2.5 h / Heating

3: 1.) BuLi, 2.) CuCC-C(OMe)Me₂ / 1.) hexane, THF, HMPA, -78 deg C, 30 min, 2.) 18 h -> room temperature

With n-butyllithium; sulfuryl dichloride; potassium carbonate; In diethyl ether; acetone;
DOI:10.1246/bcsj.67.1178

Reference yield:

: 105427-88-1
methyl 3-bromo-5-chloro-2,4-dihydroxy-6-methylbenzoate

: 950-82-3
methyl 3-chloro-4,6-dimethoxy-2-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.41 g / K₂CO₃ / acetone / 2.5 h / Heating

2: 1.) BuLi, 2.) CuCC-C(OMe)Me₂ / 1.) hexane, THF, HMPA, -78 deg C, 30 min, 2.) 18 h -> room temperature

With n-butyllithium; potassium carbonate; In acetone;
DOI:10.1246/bcsj.67.1178