6110-37-8Relevant academic research and scientific papers
Dimeric orsellinic acid derivatives: Valuable intermediates for natural product synthesis
Drochner, Daniel,Huettel, Wolfgang,Bode, Silke E.,Mueller, Michael,Karl, Ulrich,Nieger, Martin,Steglich, Wolfgang
, p. 1749 - 1758 (2007)
Herein we report on the synthesis of dimeric orsellinates by the Ullmann reaction as well as by biomimetic oxidative phenolic coupling. The Ullmann reaction gives the 5,5′- and 3,3′-coupled dimeric orsellinates 9 and 10 regioselectively. Oxidative phenoli
Asymmetric synthesis of natural cis-dihydroarenediols using tetrahydroxynaphthalene reductase and its biosynthetic implications
Saha, Nirmal,Müller, Michael,Husain, Syed Masood
supporting information, p. 2204 - 2208 (2019/03/29)
Asymmetric reduction of hydroxynaphthoquinones to secondary metabolites, (3S,4R)-3,4,8- A nd (2S,4R)-2,4,8-trihydroxy-1-tetralone, a putative biosynthetic diketo intermediate and a probable natural analogue, (3S,4R)-7-acetyl-3,4,8-trihydroxy-6-methyl-3,4-
Enantioselective total synthesis of β-zearalenol from (s)-propylene oxide
Kotla, Ravindar,Murugulla, Adharvana Chari,Ruddarraju, Radhakrishnamraju,Aparna,Donthabakthuni, Shobha,Sridhar, Gattu
supporting information, p. 747 - 752 (2018/03/29)
The total synthesis of 14-membered resorcylic acid macrolide, β-zearalenol, was accomplished starting from commercially available enantiomerically pure propylene oxide and methyl 2,4-dihydroxy-6-methylbenzoate using Grignard reaction, asymmetric dihydroxy
Diarylvinylene similar structure compound and its preparation method and application
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Paragraph 0105; 0106, (2016/10/09)
The invention discloses a group of diarylethene structure similar compounds as well as a preparation method and application thereof. The provided compounds have a structure of a general formula I. Moreover, the invention further provides medicinal compositions containing the compounds serving as active ingredients. Researches discover that the compounds have pharmacological activities of resisting influenza viruses, Coxsackie B3 viruses, AIDS viruses, hepatitis B viruses, hepatitis C viruses and the like. Therefore, the invention further provides the application of the compounds and the medicinal compositions containing the compounds serving as active ingredients in preparation of anti-virus medicaments. The invention lays a foundation for deeply researching and developing the application of the compounds as clinical medicaments. The general formula I is as shown in the specification.
Synthesis of (3R,5S)-5-hydroxy-de-O-methyllasiodiplodin: A facile and stereoselective approach
Bujaranipalli, Sheshurao,Das, Saibal
supporting information, p. 3747 - 3749 (2015/06/08)
A concise and facile synthesis of (3R,5S)-5-hydroxy-de-O-methyllasiodiplodin has been demonstrated in 12 steps starting from methylacetoacetate and (±)propylene oxide. The key reactions involved are Jacobsen's hydrolytic kinetic resolution, Sharpless asymmetric epoxidation, Mitsunobu, and ring closing metathesis reaction for the construction of macrolactone with two chiral substitutions on it.
CAJANINE STRUCTURE ANALOGOUS COMPOUND, PREPARATION METHOD AND USE
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Paragraph 0071, (2014/11/13)
Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.
CAJANINE STRUCTURE ANALOGOUS COMPOUND, PREPARATION METHOD AND USE
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Paragraph 0082, (2015/01/06)
Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.
Synthesis of the pyranonaphthoquinones dehydroherbarin, (+)-astropaquinone B and (+)-astropaquinone C en route to ascomycones A and B
Wadsworth, Andrew D.,Sperry, Jonathan,Brimble, Margaret A.
experimental part, p. 2604 - 2608 (2010/09/08)
The total syntheses of the pyranonaphthoquinone natural products dehydroherbarin, (+)-astropaquinone B and (+)-astropaquinone C are described. A late stage oxidation strategy employed for the synthesis of the astropaquinones was not amenable to the conversion of dehydroherbarin into the ascomycones. The syntheses of astropaquinones B and C reported herein constitute the first total syntheses and their absolute stereochemistry was determined to be (1R,3S). Georg Thieme Verlag Stuttgart New York.
Total synthesis of (±)-cephalosol via silyl enol ether acylation
Arlt, Alexander,Koert, Ulrich
experimental part, p. 917 - 922 (2010/04/30)
An efficient total synthesis of (±)-cephalosol is reported. Key steps are the acylation of a silyl enol ether with monomethyl oxalyl chloride and the subsequent acid-mediated ring closure to the isocoumarin structure. A chemoselective allylation and the conversion of the olefin into a methyl acetate were applied to install the γ-lactone moiety. Georg Thieme Verlag Stuttgart ? New York.
Enantioselective synthesis of the 3C-protease inhibitor (-)-thysanone by a Staunton-Weinreb annulation strategy
Sperry, Jonathan,Tsz, Ying Yuen,Brimble, Margaret A.
experimental part, p. 2561 - 2569 (2009/12/25)
The total synthesis of (-)-thysanone is described. The key step involves the addition of an o-toluate anion to a lactone to create the naphthopyran framework (Staunton-Weinreb annulation). This synthesis further confirms the absolute stereochemistry of th
