ethyl 4-[2-(tert-butyldimethylsilyloxy)ethyl]-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

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Chemical Name:ethyl 4-[2-(tert-butyldimethylsilyloxy)ethyl]-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
CAS No.:1318262-30-4
Molecular Formula:C₂₈H₃₅N₃O₃Si
Molecular Weight:489.69
Hs Code.:

Synonyms:ethyl 4-[2-(tert-butyldimethylsilyloxy)ethyl]-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

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Chemical Property of ethyl 4-[2-(tert-butyldimethylsilyloxy)ethyl]-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

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Technology Process of ethyl 4-[2-(tert-butyldimethylsilyloxy)ethyl]-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

There total 4 articles about ethyl 4-[2-(tert-butyldimethylsilyloxy)ethyl]-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2999-46-4
Ethyl isocyanoacetate

: 1318262-29-1
3-[2-(tert-butyldimethylsilyloxy)ethyl]-1,3-dihydro-5-phenyl-2H-benzo-1,4-benzodiazepin-2-one

: 1318262-30-4
ethyl 4-[2-(tert-butyldimethylsilyloxy)ethyl]-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Guidance literature:: 3-[2-(tert-butyldimethylsilyloxy)ethyl]-1,3-dihydro-5-phenyl-2H-benzo-1,4-benzodiazepin-2-one; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

With diethyl chlorophosphate; In tetrahydrofuran; for 0.5h; Inert atmosphere;

Ethyl isocyanoacetate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm2001597

Reference yield:

: 1318262-28-0
1,3-dihydro-3-(2-hydroxyethyl)-5-phenyl-2H-1,4-benzodiazepin-2-one

: 1318262-30-4
ethyl 4-[2-(tert-butyldimethylsilyloxy)ethyl]-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / dichloromethane / 2.25 h / 0 - 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

2.3: 0 - 20 °C / Inert atmosphere

With 1H-imidazole; potassium tert-butylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm2001597

Reference yield:

: 1318262-25-7
methyl 2-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acetate

: 1318262-30-4
ethyl 4-[2-(tert-butyldimethylsilyloxy)ethyl]-6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / 0 - 20 °C

2.1: 1H-imidazole / dichloromethane / 2.25 h / 0 - 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

3.3: 0 - 20 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; potassium tert-butylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm2001597