4-ethynyl-N-propylcyclohex-3-enamine

Base Information

• Chemical Name: 4-ethynyl-N-propylcyclohex-3-enamine
• CAS No.: 1443762-35-3
• Molecular Formula: C₁₁H₁₇N
• Molecular Weight: 163.263
• Mol file: 1443762-35-3.mol

Synonyms:4-ethynyl-N-propylcyclohex-3-enamine

Chemical Property of 4-ethynyl-N-propylcyclohex-3-enamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-ethynyl-N-propylcyclohex-3-enamine

There total 5 articles about 4-ethynyl-N-propylcyclohex-3-enamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → 4-ethynyl-N-propylcyclohex-3-enamine (1443762-35-3)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: formic acid; copper(II) sulfate / dichloromethane / 16 h / 20 °C / Inert atmosphere

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4: triphenylphosphine; iodine; 1H-imidazole / dichloromethane / 16 h / Inert atmosphere

5: acetonitrile; diethylamine / Resolution of racemate; Inert atmosphere

With 1H-imidazole; formic acid; iodine; sodium tris(acetoxy)borohydride; copper(II) sulfate; acetic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; diethylamine; acetonitrile;

DOI:10.1021/jm400520c

Reference yield:

8-ethynyl-1,4-dioxaspiro[4.5]decan-8-ol (70097-74-4) → 4-ethynyl-N-propylcyclohex-3-enamine (1443762-35-3)

Guidance literature:

Multi-step reaction with 4 steps

1: formic acid; copper(II) sulfate / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: triphenylphosphine; iodine; 1H-imidazole / dichloromethane / 16 h / Inert atmosphere

4: acetonitrile; diethylamine / Resolution of racemate; Inert atmosphere

With 1H-imidazole; formic acid; iodine; sodium tris(acetoxy)borohydride; copper(II) sulfate; acetic acid; triphenylphosphine; In dichloromethane; diethylamine; acetonitrile;

DOI:10.1021/jm400520c

Reference yield:

1-ethynyl-4-propylaminocyclohexan-1-ol (1443762-33-1) → 4-ethynyl-N-propylcyclohex-3-enamine (1443762-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; iodine; 1H-imidazole / dichloromethane / 16 h / Inert atmosphere

2: acetonitrile; diethylamine / Resolution of racemate; Inert atmosphere

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; diethylamine; acetonitrile;

DOI:10.1021/jm400520c

upstream raw materials:

4-ethynyl-N-propylcyclohex-3-enamine

cyclohexanedione monoethylene ketal

8-ethynyl-1,4-dioxaspiro[4.5]decan-8-ol

4-ethynyl-4-hydroxycyclohexan-1-one