(R)-N-((R)-5-formyl-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Base Information

Chemical Name:(R)-N-((R)-5-formyl-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide
CAS No.:925456-57-1
Molecular Formula:C₂₉H₂₆N₂O₄S
Molecular Weight:498.602
Hs Code.:

Synonyms:(R)-N-((R)-5-formyl-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

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Chemical Property of (R)-N-((R)-5-formyl-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

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Technology Process of (R)-N-((R)-5-formyl-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

There total 7 articles about (R)-N-((R)-5-formyl-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.7%

: 925456-55-9
(R)-N-((R)-5-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

: 925456-57-1
(R)-N-((R)-5-formyl-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Guidance literature:: With manganese(IV) oxide; In dichloromethane; acetone; at 20 ℃; for 16h;
DOI:10.1021/jm061224g

Reference yield:

: 883998-02-5
(R)-(1-amino-2,3-dihydro-1H-inden-5-yl)methanol

: 925456-57-1
(R)-N-((R)-5-formyl-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / HOBt; silica-supported carbodiimide / tetrahydrofuran; dimethylformamide / 36 h / 20 - 35 °C

2: 70.7 percent / MnO₂ / acetone; CH₂Cl₂ / 16 h / 20 °C

With manganese(IV) oxide; silica-supported carbodiimide; benzotriazol-1-ol; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm061224g

Reference yield:

: 358751-18-5
1-hydroxy-indan-5-carboxylic acid methyl ester

: 925456-57-1
(R)-N-((R)-5-formyl-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenylphosphoryl azide / toluene / 0.08 h / -10 °C

1.2: DBU / toluene / 20 °C

2.1: LiAlH₄ / tetrahydrofuran / -15 - 20 °C

3.1: 55 percent / HOBt; silica-supported carbodiimide / tetrahydrofuran; dimethylformamide / 36 h / 20 - 35 °C

4.1: 70.7 percent / MnO₂ / acetone; CH₂Cl₂ / 16 h / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; silica-supported carbodiimide; diphenylphosphoranyl azide; benzotriazol-1-ol; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm061224g