(R)-N-((R)-5-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Base Information

Chemical Name:(R)-N-((R)-5-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide
CAS No.:925456-55-9
Molecular Formula:C₂₉H₂₈N₂O₄S
Molecular Weight:500.618
Hs Code.:

Synonyms:(R)-N-((R)-5-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

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Chemical Property of (R)-N-((R)-5-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

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Technology Process of (R)-N-((R)-5-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

There total 5 articles about (R)-N-((R)-5-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 883998-02-5
(R)-(1-amino-2,3-dihydro-1H-inden-5-yl)methanol

: 193634-01-4
(R)-3-(naphthalene-2-sulfonamido)-3-phenylpropanoic acid

: 925456-55-9
(R)-N-((R)-5-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Guidance literature:: With silica-supported carbodiimide; benzotriazol-1-ol; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 - 35 ℃; for 36h;
DOI:10.1021/jm061224g

Reference yield:

: 358751-18-5
1-hydroxy-indan-5-carboxylic acid methyl ester

: 925456-55-9
(R)-N-((R)-5-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenylphosphoryl azide / toluene / 0.08 h / -10 °C

1.2: DBU / toluene / 20 °C

2.1: LiAlH₄ / tetrahydrofuran / -15 - 20 °C

3.1: 55 percent / HOBt; silica-supported carbodiimide / tetrahydrofuran; dimethylformamide / 36 h / 20 - 35 °C

With lithium aluminium tetrahydride; silica-supported carbodiimide; diphenylphosphoranyl azide; benzotriazol-1-ol; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm061224g

Reference yield:

: 1-azido-indan-5-carboxylic acid methyl ester

: 925456-55-9
(R)-N-((R)-5-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / -15 - 20 °C

2: 55 percent / HOBt; silica-supported carbodiimide / tetrahydrofuran; dimethylformamide / 36 h / 20 - 35 °C

With lithium aluminium tetrahydride; silica-supported carbodiimide; benzotriazol-1-ol; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm061224g