1,1-dimethylethyl (3R)-3-({[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}carbonyl)-4-morpholinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (3R)-3-({[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}carbonyl)-4-morpholinecarboxylate
CAS No.:1361330-33-7
Molecular Formula:C₂₆H₃₃N₅O₅
Molecular Weight:495.579
Hs Code.:

Synonyms:1,1-dimethylethyl (3R)-3-({[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}carbonyl)-4-morpholinecarboxylate

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Chemical Property of 1,1-dimethylethyl (3R)-3-({[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}carbonyl)-4-morpholinecarboxylate

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Technology Process of 1,1-dimethylethyl (3R)-3-({[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}carbonyl)-4-morpholinecarboxylate

There total 5 articles about 1,1-dimethylethyl (3R)-3-({[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}carbonyl)-4-morpholinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 869681-70-9
(R)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester

: 1361330-32-6
1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-amine

: 1361330-33-7
1,1-dimethylethyl (3R)-3-({[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}carbonyl)-4-morpholinecarboxylate

Guidance literature:: (R)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester; With HATU; In N,N-dimethyl-formamide; for 0.0833333h;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.0833333h;

1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-amine; In N,N-dimethyl-formamide; for 3h;

Reference yield:

: 1240518-02-8
3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile

: 1361330-33-7
1,1-dimethylethyl (3R)-3-({[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}carbonyl)-4-morpholinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

2.1: HATU / N,N-dimethyl-formamide / 0.08 h

2.2: 0.08 h

2.3: 3 h

With lithium aluminium tetrahydride; HATU; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 94088-46-7
2-fluoro-6-methoxybenzonitrile

: 1361330-33-7
1,1-dimethylethyl (3R)-3-({[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}carbonyl)-4-morpholinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

4.1: HATU / N,N-dimethyl-formamide / 0.08 h

4.2: 0.08 h

4.3: 3 h

With lithium aluminium tetrahydride; hydrazine hydrate; HATU; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;