94088-46-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-6-methoxybenzonitrile is used as a key intermediate in the synthesis of various pharmaceutical compounds for its unique fluorinated structure, which can impart specific properties to the final drug molecules, enhancing their efficacy and selectivity.
Used in Agrochemical Industry:
FMBN serves as a crucial building block in the development of agrochemicals, where its fluorinated nature can improve the performance and selectivity of the resulting products, contributing to more effective crop protection agents.
Used in Material Science:
2-Fluoro-6-methoxybenzonitrile is utilized in the creation of advanced materials, such as polymers and coatings, that benefit from the incorporation of fluorine atoms. This can lead to improved properties like chemical resistance, thermal stability, and non-stick characteristics.
Used in Research and Development:
FMBN is employed as a versatile compound in academic and industrial research settings, where its unique properties are explored for potential applications in new chemical reactions, synthesis methods, and innovative material development.

InChI:InChI=1/C8H6FNO/c1-11-8-4-2-3-7(9)6(8)5-10/h2-4H,1H3

Upstream product

• 1897-52-5 2,6 difluorobenzonitrile 
• 124-41-4 sodium methylate 
• 171179-83-2 2-fluoro-6-methoxybenzaldoxime 
• 456-49-5 1-fluoro-3-methoxybenzene 
• 67-56-1 methanol 
• 146137-74-8 2-fluoro-6-methoxybenzaldehyde 

Downstream Products

• 27018-21-9 5-methoxy-2,4-diaminoquinazoline 
• 35212-88-5 methyl 3-amino-4-methoxybenzo[b]thiophene-2-carboxylate 
• 146137-74-8 2-fluoro-6-methoxybenzaldehyde 
• 177995-40-3 4-methoxy-3-amino-1,2-benzisoxazole 
• 140675-43-0 2-Fluoro-6-hydroxybenzonitrile 
• 840481-53-0 3-cyano-2-fluoro-4-methoxybenzoic acid 
• 886362-07-8 4-(methyloxy)-1H-indazol-3-amine 
• 120484-50-6 1-(2-Fluoro-6-methoxyphenyl)ethanone 
• 1354928-62-3 C₁₇H₁₁FO₄ 
• 93339-98-1 1-(2-fluoro-6-hydroxyphenyl)ethan-1-one 
• 1240517-27-4 3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}-N,N-dimethylbenzamide 
• 1240515-89-2 N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide 
• 1373162-40-3 C₂₃H₂₃ClN₄O₄S₂ 
• 1240517-21-8 N-[(4-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide 

Relevant academic research and scientific papers

One pot synthesis of aryl nitriles from aromatic aldehydes in a water environment

In this study, we found a green method to obtain aryl nitriles from aromatic aldehyde in water. This simple process was modified from a conventional method. Compared with those approaches, we used water as the solvent instead of harmful chemical reagents. In this one-pot conversion, we got twenty-five aryl nitriles conveniently with pollution to the environment being minimized. Furthermore, we confirmed the reaction mechanism by capturing the intermediates, aldoximes.

TRIAZOLOPYRIDINE COMPOUNDS AND USES THEREOF

A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R6, R7 and R8 are as defined herein.

IMIDAZOPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER

A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R3, R4, R6, and R7 are as defined herein.

Synthesis of aryl dihydrothiazol acyl shikonin ester derivatives as anticancer agents through microtubule stabilization

The high incidence of cancer and the side effects of traditional anticancer drugs motivate the search for new and more effective anticancer drugs. In this study, we synthesized 17 kinds of aryl dihydrothiazol acyl shikonin ester derivatives and evaluated their anticancer activity through MTT assay. Among them, C13 showed better antiproliferation activity with IC50 = 3.14 ± 0.21 μM against HeLa cells than shikonin (IC50 = 5.75 ± 0.47 μM). We then performed PI staining assay, cell cycle distribution, and cell apoptosis analysis for C13 and found that it can cause cell arrest in G2/M phase, which leads to cell apoptosis. This derivative can also reduce the adhesive ability of HeLa cells. Docking simulation and confocal microscopy assay results further indicated that C13 could bind well to the tubulin at paclitaxel binding site, leading to tubulin polymerization and mitotic disruption.

USE OF A QUINAZOLINE COMPOUND IN PREPARING A MEDICAMENT AGAINST FLAVIVIRIDAE VIRUS

Disclosed is a use of a quinazoline compound of Formula I having 2,4-diaminoquinazoline as a parent nucleus in preparation of a medicament for treating diseases caused by flaviviridae infection, especially a use in combating Hepatitis C virus infection and Dengue fever virus infection.

Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors

The results of a high-throughput screening assay using the DENV-2 replicon showed that the 2,4-diaminoquinazoline derivative 4a has a high dengue virus inhibitory activity (EC50 = 0.15 μM). A series of 2,4-diaminoquinazoline derivatives based on 4a as a lead compound were synthesized and subjected to structure-antidengue activity relationship studies. Among the series of 2,4-diaminoquinazoline derivative probed, 4o was observed to display both the highest antiviral potency (EC50 = 2.8 nM, SI > 1000) and an excellent pharmacokinetic profile.

THIOAMIDE COMPOUNDS FOR COMBATING ANIMAL PEST

The present invention relates to thioamide compounds of the general formula (I) and to the agriculturally useful salts thereof and to compositions comprising such compounds. The invention also relates to the use of the thioamide compounds, of their salts or of compositions comprising them for combating animal pests. wherein R1,R2, R3,R4,R6 and X are defined as in the description.

NOVEL 2-CYANO-3-(HALO)ALKOXY-BENZENESULFONAMIDE COMPOUNDS FOR COMBATING ANIMAL PESTS

The invention relates to 2-cyano-3-(halo)alkoxy-benzenesulfonamide compounds (I), where the variables Alk and R1 to R5 are as defined in claim 1, and/or to their agriculturally useful salts. Moreover, the present invention relates to: the use of compounds (I) and/or their salts for combating animal pests; agricultural compositions comprising such an amount of at least one compound of the general formula (I) and/or at least one agriculturally useful salt of (I) and at least one inert liquid and/or solid agronomically acceptable carrier that it has a pesticidal action and, if desired, at least one surfactant; and a method of combating animal pests which comprises contacting the animal pests, their habit, breeding ground, food supply, plant, seed, soil, area, material or environment in which the animal pests are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from animal attack or infestation with a pesticidally effective amount of at least one2-cyano-3-(halo)alkoxy-benzenesulfonamide compound of the formula (I) and/or at least one agriculturally acceptable salt thereof; a method for the for the protection of seeds from soil insects and of the resulting plant's roots and shoots from soil and foliar insects comprising contacting the seeds before sowing and/or after pregermination with a 2-cyano-3-(halo)alkoxy-benzenesulfonamide compound of the general formula (I).

Synthesis of [1]Benzothieno[3,2-d]pyrimidines Substituted with Electron Donating Substituents on the Benzene Ring

Various 2-fluorobenzonitriles were converted to the corresponding 3-amino[1]benzothiophenecarboxylic acid esters, which in turn were annulated with formamidine or various equivalents to produce the desired tricyclic benzothienopyrimidines. Various methoxy and nitro/amino substituants were placed on the phenyl ring, requiring several different strategies to prepare the desired benzothiophenes. Several different pyrimidone annulations were also required. The use of an electron rich 2-bromobenzonitrile in a four-step one-pot low temperature lithiation sequence to produce highly electron-rich amino[1]benzothiophenecarboxylate esters is also described. The synthesis of 7-amino-8-fluoro[1]benzothieno[3,2-d]pyrimid-4(3H)-one was relatively straightforward, but synthesis of the corresponding 7-amino-8-protio analogue proved to be very difficult, and required several approaches before a successful one was found.