4-[4-(4-hydroxymethyl-2-chloro-6-methylphenylamino)pyrimidin-4-ylamino]benzonitrile

Base Information

Chemical Name:4-[4-(4-hydroxymethyl-2-chloro-6-methylphenylamino)pyrimidin-4-ylamino]benzonitrile
CAS No.:500293-23-2
Molecular Formula:C₁₉H₁₆ClN₅O
Molecular Weight:365.822
Hs Code.:

Synonyms:4-[4-(4-hydroxymethyl-2-chloro-6-methylphenylamino)pyrimidin-4-ylamino]benzonitrile

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Chemical Property of 4-[4-(4-hydroxymethyl-2-chloro-6-methylphenylamino)pyrimidin-4-ylamino]benzonitrile

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Technology Process of 4-[4-(4-hydroxymethyl-2-chloro-6-methylphenylamino)pyrimidin-4-ylamino]benzonitrile

There total 7 articles about 4-[4-(4-hydroxymethyl-2-chloro-6-methylphenylamino)pyrimidin-4-ylamino]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 943826-91-3
4-[2-(4-cyanophenylamino)pyrimidin-4-ylamino]-3-chloro-5-methylbenzoic acid ethyl ester

: 500293-23-2
4-[4-(4-hydroxymethyl-2-chloro-6-methylphenylamino)pyrimidin-4-ylamino]benzonitrile

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 20h;
DOI:10.1016/j.ejmech.2006.11.014

Reference yield:

: C₁₉H₁₄ClN₅O₂

: 500293-23-2
4-[4-(4-hydroxymethyl-2-chloro-6-methylphenylamino)pyrimidin-4-ylamino]benzonitrile

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 5 - 20 ℃; Inert atmosphere;

Reference yield:

: 40800-65-5
1-amino-2-methylbenzene-4-carboxylic acid ethyl ester

: 500293-23-2
4-[4-(4-hydroxymethyl-2-chloro-6-methylphenylamino)pyrimidin-4-ylamino]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / N-chlorosuccinimide / acetonitrile / 1 h / Heating

2: 32 percent / hydrochloric acid / 16 h / Heating

3: 27 percent / LiAlH₄ / tetrahydrofuran / 20 h / 0 - 20 °C

With hydrogenchloride; N-chloro-succinimide; lithium aluminium tetrahydride; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.ejmech.2006.11.014