2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

Base Information

Chemical Name:2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine
CAS No.:1445830-67-0
Molecular Formula:C₂₅H₂₆N₆O₂
Molecular Weight:442.52
Hs Code.:

Synonyms:2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

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Chemical Property of 2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

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Technology Process of 2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

There total 1 articles about 2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1445831-35-5
2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine

: 19524-06-2
4-bromopyridine hydrochloride

: 1445830-67-0
2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 105 ℃; for 2h;

Reference yield:

: 1445830-67-0
2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

: 1445830-83-0
2-{5-cyclopropyl-1-[4-(difluoromethoxy)-2,6-difluorobenzyl]-4-methyl-1H-pyrazol-3-yl}-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 2 h / 20 - 75 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

2.2: 20 °C

With trifluorormethanesulfonic acid; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; mineral oil;

Reference yield:

: 1445830-67-0
2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

: 1445830-66-9
2,4-dichloro-3-({5-cyclopropyl-3-[5-methoxy-4-((pyridin-4-yl)amino)pyrimidin-2-yl]-4-methyl-1H-pyrazol-1-yl}methyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 2 h / 20 - 75 °C

2: sodium hydride / tetrahydrofuran; paraffin oil / 20 h / 20 °C

With trifluorormethanesulfonic acid; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; paraffin oil;