methyl (3S,3'S)-3--3-(4-methoxyphenyl)propionate

Base Information

Chemical Name:methyl (3S,3'S)-3--3-(4-methoxyphenyl)propionate
CAS No.:159848-83-6
Molecular Formula:C₃₂H₄₉NO₇Si
Molecular Weight:587.829
Hs Code.:

methyl (3S,3'S)-3-<N-tert-butoxycarbonyl-3'-tert-butyldimethylsiloxy-3'-(4-methoxyphenyl)propylamino>-3-(4-methoxyphenyl)propionate

Synonyms:methyl (3S,3'S)-3--3-(4-methoxyphenyl)propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (3S,3'S)-3--3-(4-methoxyphenyl)propionate

Chemical Property:

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Technology Process of methyl (3S,3'S)-3--3-(4-methoxyphenyl)propionate

There total 16 articles about methyl (3S,3'S)-3--3-(4-methoxyphenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

: 24424-99-5
di-tert-butyl dicarbonate

: 159848-82-5
methyl (3S,3'S)-3-<3'-tert-butyldimethylsiloxy-3'-(4-methoxyphenyl)propylamino>-3-(4-methoxyphenyl)propionate

: 159848-83-6
methyl (3S,3'S)-3--3-(4-methoxyphenyl)propionate

Guidance literature:: With triethylamine; In 1,4-dioxane; at 50 ℃; for 14h;
DOI:10.1016/S0040-4020(01)85520-4

Reference yield:

: 24393-56-4
ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate

: 159848-83-6
methyl (3S,3'S)-3--3-(4-methoxyphenyl)propionate

Guidance literature:: Multi-step reaction with 8 steps

1: 92 percent / AD-mix-β, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 4 deg C, 11 h then rt., 4 h

2: 73 percent / pyridine / 18 h / 4 °C

3: 87 percent / LiCl / dimethylformamide / 14 h / 85 °C

4: 91 percent / HCO₂NH₄ / 5percent Pd-C / methanol / 2 h / 0 °C

5: 99.6 percent / imidazole / dimethylformamide / 14 h / Ambient temperature

6: 95 percent / 1.5M DIBAL / CH₂Cl₂; toluene / 0.25 h / -78 °C

7: 74 percent / 1M NaBH₃CN / methanol; acetic acid; tetrahydrofuran / 10 h / 0 - 10 °C

8: 99.6 percent / Et₃N / dioxane / 14 h / 50 °C

With pyridine; 1H-imidazole; methanesulfonamide; AD-mix-β; ammonium formate; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)85520-4

Reference yield:

: ethyl (2RS,3R)-2-chloro-3-hydroxy-3-(4-methoxyphenyl)propionate

: 159848-83-6
methyl (3S,3'S)-3--3-(4-methoxyphenyl)propionate

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / HCO₂NH₄ / 5percent Pd-C / methanol / 2 h / 0 °C

2: 99.6 percent / imidazole / dimethylformamide / 14 h / Ambient temperature

3: 95 percent / 1.5M DIBAL / CH₂Cl₂; toluene / 0.25 h / -78 °C

4: 74 percent / 1M NaBH₃CN / methanol; acetic acid; tetrahydrofuran / 10 h / 0 - 10 °C

5: 99.6 percent / Et₃N / dioxane / 14 h / 50 °C

With 1H-imidazole; ammonium formate; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)85520-4