ethyl 1-(4-chlorobenzoyl)-α-oxo-3-indoleacetate

Base Information

• Chemical Name: ethyl 1-(4-chlorobenzoyl)-α-oxo-3-indoleacetate
• CAS No.: 73790-10-0
• Molecular Formula: C₁₉H₁₄ClNO₄
• Molecular Weight: 355.777
• Mol file: 73790-10-0.mol

Synonyms:ethyl 1-(4-chlorobenzoyl)-α-oxo-3-indoleacetate

Chemical Property of ethyl 1-(4-chlorobenzoyl)-α-oxo-3-indoleacetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 1-(4-chlorobenzoyl)-α-oxo-3-indoleacetate

There total 1 articles about ethyl 1-(4-chlorobenzoyl)-α-oxo-3-indoleacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl 2-(1H-indol-3-yl)-2-oxoacetate (51079-10-8) + 4-chloro-benzoyl chloride (122-01-0) → ethyl 1-(4-chlorobenzoyl)-α-oxo-3-indoleacetate (73790-10-0)

Guidance literature:

In pyridine; for 3h; Heating;

DOI:10.1021/jo01302a025

Reference yield: 82.0%

ethyl 1-(4-chlorobenzoyl)-α-oxo-3-indoleacetate (73790-10-0) → ethyl 1-(4-chlorobenzoyl)-α,α-difluoro-3-indoleacetate (73790-03-1)

Guidance literature:

With diethylamino-sulfur trifluoride; at 80 - 90 ℃; for 3h;

DOI:10.1021/jo01302a025

upstream raw materials:

ethyl 2-(1H-indol-3-yl)-2-oxoacetate

4-chloro-benzoyl chloride

Downstream raw materials:

ethyl 1-(4-chlorobenzoyl)-α,α-difluoro-3-indoleacetate

Refernces