N-(4-aminothiophen-3-yl)-4-[1-(2-dimethylaminoethyl)-3-(indan-5-yl)ureidomethyl]benzamide

Base Information

Chemical Name:N-(4-aminothiophen-3-yl)-4-[1-(2-dimethylaminoethyl)-3-(indan-5-yl)ureidomethyl]benzamide
CAS No.:1196982-54-3
Molecular Formula:C₂₆H₃₁N₅O₂S
Molecular Weight:477.63
Hs Code.:

Synonyms:N-(4-aminothiophen-3-yl)-4-[1-(2-dimethylaminoethyl)-3-(indan-5-yl)ureidomethyl]benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-aminothiophen-3-yl)-4-[1-(2-dimethylaminoethyl)-3-(indan-5-yl)ureidomethyl]benzamide

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Technology Process of N-(4-aminothiophen-3-yl)-4-[1-(2-dimethylaminoethyl)-3-(indan-5-yl)ureidomethyl]benzamide

There total 5 articles about N-(4-aminothiophen-3-yl)-4-[1-(2-dimethylaminoethyl)-3-(indan-5-yl)ureidomethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1034494-18-2
4-[1-(2-dimethylaminoethyl)-3-(indan-5-yl)ureidomethyl] benzoic acid

: 90069-81-1
thiophene-3,4-diamine dihydrochloride

: 1196982-54-3
N-(4-aminothiophen-3-yl)-4-[1-(2-dimethylaminoethyl)-3-(indan-5-yl)ureidomethyl]benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 67853-01-4
benzyl 4-(hydroxymethyl)benzoate

: 1196982-54-3
N-(4-aminothiophen-3-yl)-4-[1-(2-dimethylaminoethyl)-3-(indan-5-yl)ureidomethyl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0.83 h / 20 °C / Cooling with ice

2: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

3: dichloromethane / 15 h / 20 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 29 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1034494-08-0
4-methanesulfonyloxymethylbenzoic acid benzyl ester

: 1196982-54-3
N-(4-aminothiophen-3-yl)-4-[1-(2-dimethylaminoethyl)-3-(indan-5-yl)ureidomethyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2: dichloromethane / 15 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 29 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;