C₂₁H₁₄NO₃Cl

Base Information

• Chemical Name: C₂₁H₁₄NO₃Cl
• CAS No.: 947409-45-2
• Molecular Formula: C₂₁H₁₄ClNO₃
• Molecular Weight: 363.8
• Mol file: 947409-45-2.mol

Synonyms:C₂₁H₁₄NO₃Cl

Chemical Property of C₂₁H₁₄NO₃Cl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₄NO₃Cl

There total 3 articles about C₂₁H₁₄NO₃Cl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-chloro-6-nitrophenyl acetylene (947409-39-4) + benzophenone (119-61-9) → C21H14NO3Cl (947409-45-2)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/jo070812e

Reference yield:

6-chloro-2-nitrotoluene (83-42-1) → C21H14NO3Cl (947409-45-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 16 h / 140 °C

1.2: 9 h / 0 - 20 °C

2.1: potassium carbonate / methanol / 4 h / 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0.17 h / -78 °C

3.2: 1.5 h / -78 - 20 °C

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexanes; N,N-dimethyl-formamide;

Reference yield:

2-chloro-6-nitrobenzaldehyde (6361-22-4) → C21H14NO3Cl (947409-45-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / methanol / 4 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0.17 h / -78 °C

2.2: 1.5 h / -78 - 20 °C

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexanes;

upstream raw materials:

2-chloro-6-nitrophenyl acetylene

benzophenone

6-chloro-2-nitrotoluene

2-chloro-6-nitrobenzaldehyde

Downstream raw materials:

C₂₈H₂₁ClN₄O₃

C₂₈H₂₁ClN₄O₃

Refernces

• 1、 -. "METHOD FOR MAKING BIARYL COMPOUNDS, COMPOUNDS MADE BY THE METHOD, AND METHOD FOR THEIR USE". Page/Page column 45; 101. . Retrieved 2009/01/23.