(E)-methyl 2-<1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>-2'-hydroxyethoxymethyl>-3-dimethyl(phenyl)silyl-2-enoate

Base Information

Chemical Name:(E)-methyl 2-<1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>-2'-hydroxyethoxymethyl>-3-dimethyl(phenyl)silyl-2-enoate
CAS No.:145746-09-4
Molecular Formula:C₂₃H₃₆O₆S₂Si
Molecular Weight:500.753
Hs Code.:

Synonyms:(E)-methyl 2-<1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>-2'-hydroxyethoxymethyl>-3-dimethyl(phenyl)silyl-2-enoate

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Chemical Property of (E)-methyl 2-<1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>-2'-hydroxyethoxymethyl>-3-dimethyl(phenyl)silyl-2-enoate

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Technology Process of (E)-methyl 2-<1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>-2'-hydroxyethoxymethyl>-3-dimethyl(phenyl)silyl-2-enoate

There total 9 articles about (E)-methyl 2-<1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>-2'-hydroxyethoxymethyl>-3-dimethyl(phenyl)silyl-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 138175-71-0
(E)-methyl 2-<2'-tert-butyldimethylsiloxy-1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>ethoxymethyl>-3-dimethyl(phenyl)silylprop-2-enoate

: 145746-09-4
(E)-methyl 2-<1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>-2'-hydroxyethoxymethyl>-3-dimethyl(phenyl)silyl-2-enoate

Guidance literature:: With pyridine; hydrogen fluoride; In acetonitrile; 1) room temperature, 10 h, 2) 35 deg C, 24 h;
DOI:10.1039/P19920002735

Reference yield:

: 56169-20-1
2-(2,2-dimethoxyethyl)1,3-dithiane

: 145746-09-4
(E)-methyl 2-<1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>-2'-hydroxyethoxymethyl>-3-dimethyl(phenyl)silyl-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) N,N,N',N'-tetramethylethylenediamine, butyllithium / 1) THF, hexane, -30 deg C, 90 min, 2) THF, -78 deg C, 5 min

2: 1) KH / 1) THF, room temperature, 1 h, 2) THF, a) 0 deg C, 20 min, b) room temperature, 10 min

3: 85 percent / 40percent aq. HF, pyridine / acetonitrile / 1) room temperature, 10 h, 2) 35 deg C, 24 h

With pyridine; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen fluoride; potassium hydride; In acetonitrile;
DOI:10.1039/P19920002735

Reference yield:

: 145745-77-3
(Z)-methyl 2-bromomethyl-3-dimethyl(phenyl)silylprop-2-enoate

: 145746-09-4
(E)-methyl 2-<1'-<2''-(2''',2'''-dimethoxyethyl)-1'',3''-dithian-2''-yl>-2'-hydroxyethoxymethyl>-3-dimethyl(phenyl)silyl-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) KH / 1) THF, room temperature, 1 h, 2) THF, a) 0 deg C, 20 min, b) room temperature, 10 min

2: 85 percent / 40percent aq. HF, pyridine / acetonitrile / 1) room temperature, 10 h, 2) 35 deg C, 24 h

With pyridine; hydrogen fluoride; potassium hydride; In acetonitrile;
DOI:10.1039/P19920002735