({(4R,5R)-5-[3-(benzyloxy)propyl]-2,2,4-trimethyl-1,3-dioxolan-4-yl}methoxy)(tert-butyl)dimethylsilane

Base Information

Chemical Name:({(4R,5R)-5-[3-(benzyloxy)propyl]-2,2,4-trimethyl-1,3-dioxolan-4-yl}methoxy)(tert-butyl)dimethylsilane
CAS No.:911423-93-3
Molecular Formula:C₂₃H₄₀O₄Si
Molecular Weight:408.654
Hs Code.:

Synonyms:({(4R,5R)-5-[3-(benzyloxy)propyl]-2,2,4-trimethyl-1,3-dioxolan-4-yl}methoxy)(tert-butyl)dimethylsilane

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Chemical Property of ({(4R,5R)-5-[3-(benzyloxy)propyl]-2,2,4-trimethyl-1,3-dioxolan-4-yl}methoxy)(tert-butyl)dimethylsilane

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Technology Process of ({(4R,5R)-5-[3-(benzyloxy)propyl]-2,2,4-trimethyl-1,3-dioxolan-4-yl}methoxy)(tert-butyl)dimethylsilane

There total 6 articles about ({(4R,5R)-5-[3-(benzyloxy)propyl]-2,2,4-trimethyl-1,3-dioxolan-4-yl}methoxy)(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 312492-85-6
{(4R,5R)-5-[3-(benzyloxy)propyl]-2,2,4-trimethyl-1,3-dioxolan-4-yl}methanol

: 911423-93-3
({(4R,5R)-5-[3-(benzyloxy)propyl]-2,2,4-trimethyl-1,3-dioxolan-4-yl}methoxy)(tert-butyl)dimethylsilane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1002/ejoc.200600113

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 911423-93-3
({(4R,5R)-5-[3-(benzyloxy)propyl]-2,2,4-trimethyl-1,3-dioxolan-4-yl}methoxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 11.021 g / tetrahydrofuran / 4 h / 80 °C

2.1: AD-Mix β; methanesulfonamide; water / 2-methyl-propan-2-ol / 14 h / 20 °C

2.2: 6.329 g / CSA / 14 h / 20 °C

3.1: 94 percent / DIBAL-H / tetrahydrofuran; hexane / 14 h / 20 °C

4.1: 99 percent / imidazole / dimethylformamide / 12 h / 20 °C

With 1H-imidazole; methanesulfonamide; water; diisobutylaluminium hydride; 1,4-bis(9-O-dihydroquinidine)phthalazine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/ejoc.200600113

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 911423-93-3
({(4R,5R)-5-[3-(benzyloxy)propyl]-2,2,4-trimethyl-1,3-dioxolan-4-yl}methoxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl chloride; DMSO / CH₂Cl₂ / 0.5 h / -78 °C

1.2: N-ethyldiisopropylamine / CH₂Cl₂ / 0.5 h / -78 - -60 °C

2.1: 11.021 g / tetrahydrofuran / 4 h / 80 °C

3.1: AD-Mix β; methanesulfonamide; water / 2-methyl-propan-2-ol / 14 h / 20 °C

3.2: 6.329 g / CSA / 14 h / 20 °C

4.1: 94 percent / DIBAL-H / tetrahydrofuran; hexane / 14 h / 20 °C

5.1: 99 percent / imidazole / dimethylformamide / 12 h / 20 °C

With 1H-imidazole; oxalyl dichloride; methanesulfonamide; water; diisobutylaluminium hydride; dimethyl sulfoxide; 1,4-bis(9-O-dihydroquinidine)phthalazine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/ejoc.200600113