1-methyl-3-benzyloxycarbonyl-5-methoxycarbonyl pyrazole

Base Information

• Chemical Name: 1-methyl-3-benzyloxycarbonyl-5-methoxycarbonyl pyrazole
• CAS No.: 356759-65-4
• Molecular Formula: C₁₄H₁₄N₂O₄
• Molecular Weight: 274.276
• Mol file: 356759-65-4.mol

Synonyms:1-methyl-3-benzyloxycarbonyl-5-methoxycarbonyl pyrazole

Chemical Property of 1-methyl-3-benzyloxycarbonyl-5-methoxycarbonyl pyrazole

Chemical Property:

Purity/Quality:

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Technology Process of 1-methyl-3-benzyloxycarbonyl-5-methoxycarbonyl pyrazole

There total 1 articles about 1-methyl-3-benzyloxycarbonyl-5-methoxycarbonyl pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

benzyl bromide (100-39-0) + 5-(methoxycarbonyl)-1-methyl-1H-pyrazole-3-carboxylic acid (117860-56-7) → 1-methyl-3-benzyloxycarbonyl-5-methoxycarbonyl pyrazole (356759-65-4)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1021/jm0108404

Reference yield: 88.0%

1-methyl-3-benzyloxycarbonyl-5-methoxycarbonyl pyrazole (356759-65-4) → 3-benzyloxycarbonyl-1-methylpyrazole-5-carboxylic acid (356759-66-5)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; at 20 ℃; for 24h;

DOI:10.1021/jm0108404

Reference yield:

1-methyl-3-benzyloxycarbonyl-5-methoxycarbonyl pyrazole (356759-65-4) → 5-(3-Benzyl-8-chloromethyl-4-hydroxy-7,8-dihydro-3H-pyrrolo[3,2-e]indazole-6-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid {5-[5-(2-carbamimidoyl-ethylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-yl}-amide; hydrochloride

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / 2 N KOH / dioxane / 24 h / 20 °C

2: 52 percent / Hunig's base; EDCI; HOBt / dimethylformamide / 18 h / 0 - 20 °C

3: 72 percent / H₂; aq. 5percent HCl / 10percent Pd/C / methanol / 4 h / 2585.81 Torr

4: 72 percent / EDCI / dimethylformamide / 18 h

With potassium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 10percent Pd/C; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0108404

upstream raw materials:

benzyl bromide

5-(methoxycarbonyl)-1-methyl-1H-pyrazole-3-carboxylic acid

Downstream raw materials:

3-benzyloxycarbonyl-1-methylpyrazole-5-carboxylic acid