C₄₂H₅₀N₄O₁₁

Base Information

• Chemical Name: C₄₂H₅₀N₄O₁₁
• CAS No.: 1326757-08-7
• Molecular Formula: C₄₂H₅₀N₄O₁₁
• Molecular Weight: 786.879
• Mol file: 1326757-08-7.mol

Synonyms:C₄₂H₅₀N₄O₁₁

Chemical Property of C₄₂H₅₀N₄O₁₁

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₂H₅₀N₄O₁₁

There total 4 articles about C₄₂H₅₀N₄O₁₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

di-tert-butyl 4-benzyloxycarbonylamino-4-[2-(tert-butoxycarbonyl)ethyl]-heptanedioate (945744-14-9) + dopamine hydrochloride (62-31-7) → C42H50N4O11 (1326757-08-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1002/chem.201100715

Reference yield:

di-tert-butyl 4-(((benzyloxy)carbonyl)amino)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate → C42H50N4O11 (1326757-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.201100715

Reference yield:

4-amino-4-(2-tert-butoxycarbonylethyl)heptanedioic acid di-tertbutyl ester (136586-99-7) → C42H50N4O11 (1326757-08-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / 1,4-dioxane; water / 4 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/chem.201100715

upstream raw materials:

di-tert-butyl 4-benzyloxycarbonylamino-4-[2-(tert-butoxycarbonyl)ethyl]-heptanedioate

dopamine hydrochloride

4-amino-4-(2-tert-butoxycarbonylethyl)heptanedioic acid di-tertbutyl ester

benzyl chloroformate

Downstream raw materials:

C₃₄H₄₄N₄O₉