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Usage

Uses

Used in Theranostics Research:
AMINOTRIESTER is used as a research intermediate for the construction of multifunctional dendrimers. These dendrimers are designed to enhance the capabilities of theranostics by providing a well-defined structure that can be tailored for specific applications in personalized medicine. The use of AMINOTRIESTER in this context allows for the development of more effective and targeted therapies, as well as improved diagnostic tools for early detection and monitoring of diseases.

Upstream product

• 75-52-5 nitromethane 
• 1663-39-4 tert-Butyl acrylate 
• 136587-00-3 di-tert-butyl 4-<2-(tert-butoxycarbonyl)ethyl>-4-nitroheptanedicarboxylate 

Downstream Products

• 197368-00-6 di-tert-butyl 4-(3-(tert-butoxy)-3-oxopropyl)-4-isocyanatoheptanedioate 
• 220215-00-9 N,N',N''-tris[tris(2-tert-butoxycarbonyl-ethyl)methyl]-3,3',3''-(1-nitromethanetriyl)tripropanamide 
• 880359-83-1 4-(6-benzyloxycarbonyl-hexanoylamino)-4-(2-tert-butoxycarbonyl-ethyl)-heptanedioic acid di-tert-butyl ester 
• 263843-49-8 4-{3-[3-tert-butoxycarbonyl-1,1-bis-(2-tert-butoxycarbonyl-ethyl)-propylcarbamoyl]-5-nitro-benzoylamino}-4-(2-tert-butoxycarbonyl-ethyl)-heptanedioic acid di-tert-butyl ester 
• 671246-46-1 di-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate 
• 880359-78-4 4-(6-benzyloxycarbonylamino-hexanoylamino)-4-(2-tert-butoxycarbonyl-ethyl)-heptanedioic acid di-tert-butyl ester 
• 1217553-84-8 4-(2-tert-butoxycarbonyl-ethyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-heptanedioic acid di-tert-butyl ester 
• 798576-99-5 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-carboxyethyl)heptanedioic acid 
• 945744-14-9 di-tert-butyl 4-benzyloxycarbonylamino-4-[2-(tert-butoxycarbonyl)ethyl]-heptanedioate 
• 671246-47-2 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(2-carboxyethyl)heptanedioic acid 
• 926649-26-5 N-[tris(2-dodecylaminocarbonyl-ethyl)methyl]-N'-[tris(2-tert-butoxycarbonyl-ethyl)methyl]terephthaldiamide 
• 918876-49-0 4-(2-tert-butoxycarbonyl-ethyl)-4-[6-(4-methoxy-phenoxy)-hexanoylamino]-heptanedioic acid di-tert-butyl ester 
• 209679-61-8 N-{tris[(2-tert-butoxycarbonyl)ethyl]methyl}-5-nitroisophthalimide monocarboxylic acid 

Relevant academic research and scientific papers

Cascade Polymers: Syntheses and Characterization of One-Directional Arborols Based on Adamantane

Several methods for the synthesis of cascade polymers (dendritic macromolecules) on adamantane have been investigated.The synthesis of two novel, branched monomers, 4-amino-4-(3-acetoxypropyl)-1,7-diacetoxyheptane and di-tert-butyl 4-amino-4-heptanedioate, possessing 3-fold symmetry and branches emanating from a tetrahedral carbon branch point, is described.These monomers were reacted with a mono-functional adamantane core to evaluate the reaction efficiency, ease of purification of products, and spectral characteristics.

Generation effect of Newkome dendrimers on cellular uptake

Poly(amide)-based dendrimers can be used as delivery scaffolds in conjunction with the cell-penetrating peptide gH625 derived from the glycoprotein of the Herpes Simplex virus type 1. In this contribution, we aim to isolate the optimal dendrimer generation for cellular uptake for Newkome type dendrimers conjugated with gH625. For this study, we synthesized generations zero to three of the Newkome dendrimer-gH625 bioconjugate. Fluorescent microscopy experiments showed that the second and third generations are the most efficient for cellular uptake with the second generation having the synthetic advantage. The optimal second generation can be used as an improved material for a dendrimer based delivery scaffold for peptide therapeutics.

Synthesis, characterization and computational modeling of cyclen substituted with dendrimeric branches. Dendrimeric and macrocyclic moieties working together in a collective fashion

A molecular system, formed by the aza-macrocycle known as cyclen and functionalized dendrons, was synthesized in a convergent fashion. An aliphatic spacer between the two molecular units was incorporated to avoid the sterical hindrances. The N-acylation reactions to carry out the cyclen substitution, particularly those in solid state, resulted in very good yields since no further purifications were necessary. The obtained molecular system was characterized by common spectroscopic techniques. According to X-ray analysis (powder analysis), there is a random arrangement of the molecules, with an average interplanar distance (the most recurrent) of 4.8 ? between first neighbors. A theoretical study at DFT level of theory was carried out, simulating the inclusion process of Ni2+ into two different model molecules (A and C), with and without dendrons present. According to the calculated interaction energies in the inclusion process, there is a significant contribution in terms of energy (-60.89 Kcal/mol) due to the presence of functionalized dendrons, which enfold the metal ion, forming a molecular cage and increasing in this way the degree of pre-organization due to cooperative effects created by the dendrimeric environment. These molecular arrangements would be relevant in areas like catalysis, having influence on the selectivity of catalytic processes, by controlling the accessibility of the active site (the metal atom) via sterical hindrances. Further experimental work of the incorporation of metal ions of the first transition series will be done in a rational way, taking into account the theoretical results obtained so far.

Synthesis and spectroscopic characterization of a new tripodal hexadentate iron chelator incorporating catechol units

We report the synthesis and physicochemical properties of a new tripodal hexadentate chelator (catTHC) synthesized by reaction of a flexible tripodal backbone with three bidentate catechol units. To improve the efficiency of the amide coupling reaction, classical conditions using two pairs of coupling reactants were tested, and a significant reduction in reaction time was achieved by using microwave irradiation with the reactants DCC/HOBt. Subsequent removal of the benzyl protecting groups using BCl3 in dichloromethane provided the final chelator in good yield. The acid-base properties of catTHC in aqueous solution and the affinity of the ligand towards iron(III) were investigated at variable pH and in the presence of iron(III) using spectroscopic methods. The hexadentate ligand forms a 1:1 complex with iron(III) whose stability constant was determined by competition with EDTA. The values obtained for the stability constant and pFe3+ are log β110 = 36.70 and pFe3+ = 26.7.

Rapid method for reducing nitro in aliphatic nitro compound into amino

The invention discloses a rapid method for reducing nitro in an aliphatic nitro compound into amino. According to the method, raney nickel is adopted as a catalyst, hydrazine hydrate is adopted as a reducing agent, ethyl alcohol or methyl alcohol is adopted as a solvent, reaction is carried out at the reaction temperature of 60-70 DEG C, the reaction for reducing a whole aliphatic nitro compound into an aliphatic amino compound can be completed very quickly, and the reaction time does not exceed 2 hours. The method has the advantages of rapid reaction, no need of pressurization or sealing, noneed of inert gas protection, high yield and suitability for mass production.

Multifunctional degradable nanoparticles with control over size and functionalities

In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymers and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Multi-branched triazine derivative and application of same

The invention relates to a multi-branched 1,3,5-triazine derivative and an application thereof. In the invention, a multi-branched amphiphilic molecule, which is easy to prepare and is higher than 30% in total yield, is designed since a symtriazine ring is not damaged due to tolerance against various severe reaction conditions and the three chlorine atoms on a cyanuric chloride ring have unique reaction features; the multi-branched amphiphilic molecule not only can be used as a surfactant independently, but also can be combined with other cationic surfactants.

Platform Synthetic Lectins for Divalent Carbohydrate Recognition in Water

Biomimetic carbohydrate receptors (“synthetic lectins”) have potential as agents for biological research and medicine. However, although effective strategies are available for “all-equatorial” carbohydrates (glucose, etc.), the recognition of other types of saccharide under natural (aqueous) conditions is less well developed. Herein we report a new approach based on a pyrene platform with polar arches extending from aryl substituents. The receptors are compatible with axially substituted carbohydrates, and also feature two identical binding sites, thus mimicking the multivalency observed for natural lectins. A variant with negative charges forms 1:2 host/guest complexes with aminosugars, with K1>3000 m?1for axially substituted mannosamine, whereas a positively charged version binds the important α-sialyl unit with K1≈1300 m?1.

CONJUGATES AND THEIR USES IN MOLECULAR IMAGING

The present invention relates to bifunctional compounds, the bifunctional compounds for use in molecular imaging and therapy, methods of molecular imaging using the bifunctional compounds and kits including the bifunctional compounds for use molecular imaging. The bifunctional compounds have a tripodal hydroxypyridinone chelating portion and may be conjugated to a targeting group so that the compounds target specific cells or tissues in a subject.

SUGAR-LINKER-DRUG CONJUGATES

The present disclosure relates to sugar-linker-drug conjugates, of the formula [A-B-]n-L-D, wherein A is a saccharide; B is a spacer, n is an integer selected from 1 to 3; L is a linker group and D is a drug having a chemically reactive functional group selected from the group consisting of a primary or secondary amine, hydroxyl, sulfhydryl, carboxyl, aldehyde and ketone. Pharmaceutical compositions comprising the conjugates and methods of using thern are also provided.