trans-4-[(4R)-(benzyloxy)methyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:trans-4-[(4R)-(benzyloxy)methyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester
CAS No.:942428-60-6
Molecular Formula:C₂₇H₄₁NO₇
Molecular Weight:491.625
Hs Code.:

Synonyms:trans-4-[(4R)-(benzyloxy)methyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

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Chemical Property of trans-4-[(4R)-(benzyloxy)methyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

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Technology Process of trans-4-[(4R)-(benzyloxy)methyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

There total 9 articles about trans-4-[(4R)-(benzyloxy)methyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 3587-60-8
Benzyloxymethyl chloride

: 942428-59-3
4-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

: 942428-60-6
4-[(4R)-(benzyloxy)methyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 942428-60-6
4-[(4R)-(benzyloxy)methyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

: 942428-60-6
trans-4-[(4R)-(benzyloxy)methyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

Guidance literature:: With sodium hydride; In ethanol; N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

Reference yield:

: 792916-38-2
4-[1-(benzyloxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]benzoic acid ethyl ester

: 942428-60-6
trans-4-[(4R)-(benzyloxy)methyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 10 % Pd(OH)2/C / methanol / 4 h

2.1: hydrogen; trifluoroacetic acid / 5% rhodium on activated aluminium oxide / methanol / 4 h / 5320.36 Torr

2.2: 48 h

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

4.1: sodium hydride / ethanol; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

With hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10 % Pd(OH)2/C; 5% rhodium on activated aluminium oxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;