trans-4-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

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Chemical Name:trans-4-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester
CAS No.:942428-59-3
Molecular Formula:C₁₉H₃₃NO₆
Molecular Weight:371.474
Hs Code.:

Synonyms:trans-4-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

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Chemical Property of trans-4-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

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Technology Process of trans-4-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

There total 8 articles about trans-4-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 942428-60-6
trans-4-[(4R)-(benzyloxy)methyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

: 942428-59-3
trans-4-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

Guidance literature:: With hydrogen; 10 % Pd(OH)2/C; In methanol; for 16h; under 3040.2 Torr;

Reference yield: 91.0%

: 942307-44-0
4-[(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]benzoic acid ethyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 942428-59-3
4-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

Guidance literature:: 4-[(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]benzoic acid ethyl ester; With hydrogen; trifluoroacetic acid; 5% rhodium on activated aluminium oxide; In methanol; for 4h; under 5320.36 Torr;

di-tert-butyl dicarbonate; With sodium hydrogencarbonate; In 1,4-dioxane; water; for 48h;

Reference yield:

: 942307-44-0
4-[(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]benzoic acid ethyl ester

: 942428-59-3
trans-4-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; trifluoroacetic acid / 5% rhodium on activated aluminium oxide / methanol / 4 h / 5320.36 Torr

1.2: 48 h

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

3.1: sodium hydride / ethanol; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

4.1: hydrogen / 10 % Pd(OH)2/C / methanol / 16 h / 3040.2 Torr

With hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10 % Pd(OH)2/C; 5% rhodium on activated aluminium oxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;