4-Oxo-pentanoic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:4-Oxo-pentanoic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester
CAS No.:215116-94-2
Molecular Formula:C₃₅H₃₇N₃O₈
Molecular Weight:627.694
Hs Code.:

4-Oxo-pentanoic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Synonyms:4-Oxo-pentanoic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

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Chemical Property of 4-Oxo-pentanoic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

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Technology Process of 4-Oxo-pentanoic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

There total 5 articles about 4-Oxo-pentanoic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 215117-45-6
4-Oxo-pentanoic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 215116-94-2
4-Oxo-pentanoic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: With isopropyl alcohol; zinc dibromide; In dichloromethane; for 6h; Yield given; Ambient temperature;
DOI:10.1021/ja982004y

Reference yield:

: 80594-29-2
1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1H-pyrimidin-2-one

: 215116-94-2
4-Oxo-pentanoic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DCC

2: ZnBr₂

With dicyclohexyl-carbodiimide; zinc dibromide; 1: Acylation / 2: Substitution;
DOI:10.1080/07328319908044706

Reference yield:

: 3992-42-5
2'-deoxycytidine monohydrochloride

: 215116-94-2
4-Oxo-pentanoic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / pyridine, Et₃N, (dimethylamino)pyridine / 0.67 h / Ambient temperature

2: pyridine, (dimethylamino)pyridine, 1,3-dicyclohexylcarbodiimide / dioxane / 4 h / Ambient temperature

3: ZnBr₂, 2-propanol / CH₂Cl₂ / 6 h / Ambient temperature

With pyridine; dmap; triethylamine; dicyclohexyl-carbodiimide; isopropyl alcohol; zinc dibromide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ja982004y