methyl 4-[({6-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]benzoate

Base Information

Chemical Name:methyl 4-[({6-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]benzoate
CAS No.:916914-00-6
Molecular Formula:C₂₅H₂₈N₂O₅S₂
Molecular Weight:500.64
Hs Code.:

Synonyms:methyl 4-[({6-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]benzoate

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Chemical Property of methyl 4-[({6-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]benzoate

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Technology Process of methyl 4-[({6-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]benzoate

There total 6 articles about methyl 4-[({6-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 916913-91-2
methyl 4-[({6-[(1,3-thiazol-2-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]benzoate

: 513-38-2
Isobutyl iodide

: 916914-00-6
methyl 4-[({6-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]benzoate

Guidance literature:: With caesium carbonate; dimethyl amine; at 80 ℃;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 916913-82-1
methyl 4-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

: 916914-00-6
methyl 4-[({6-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

2: 73 percent / dimethylamine; Cs₂CO₃ / 80 °C

With pyridine; caesium carbonate; dimethyl amine; In dichloromethane;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 916913-78-5
methyl 4-{[(6-nitro-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

: 916914-00-6
methyl 4-[({6-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / acetic acid; iron / H₂O / 1 h

2: 66 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

3: 73 percent / dimethylamine; Cs₂CO₃ / 80 °C

With pyridine; iron; caesium carbonate; acetic acid; dimethyl amine; In dichloromethane; water;
DOI:10.1016/j.bmc.2006.08.001