(5-amino-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

Base Information

Chemical Name:(5-amino-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate
CAS No.:1333242-52-6
Molecular Formula:C₃₁H₃₅N₃O₇S
Molecular Weight:593.701
Hs Code.:

Synonyms:(5-amino-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

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Chemical Property of (5-amino-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

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Technology Process of (5-amino-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

There total 4 articles about (5-amino-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1333242-11-7
(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

: 1333242-52-6
(5-amino-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

Guidance literature:: With platinum(IV) oxide; hydrogen; In tetrahydrofuran; for 0.5h; under 2327.23 Torr;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 1333242-32-2
tert-butyl 1-(((cyclohexylsulfonyl)oxy)methyl)-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

: 1333242-52-6
(5-amino-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 10 - 20 °C

1.2: 2 h / 20 °C

2.1: platinum(IV) oxide; hydrogen / tetrahydrofuran / 0.5 h / 2327.23 Torr

With hydrogenchloride; platinum(IV) oxide; hydrogen; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 4837-38-1
cyclohexanesulfonyl chloride

: 1333242-52-6
(5-amino-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 10 - 20 °C

2.2: 2 h / 20 °C

3.1: platinum(IV) oxide; hydrogen / tetrahydrofuran / 0.5 h / 2327.23 Torr

With hydrogenchloride; platinum(IV) oxide; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2011.06.073