(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

Base Information

Chemical Name:(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate
CAS No.:1333242-11-7
Molecular Formula:C₃₁H₃₃N₃O₉S
Molecular Weight:623.684
Hs Code.:

Synonyms:(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

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Chemical Property of (5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

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Technology Process of (5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

There total 3 articles about (5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1333242-32-2
tert-butyl 1-(((cyclohexylsulfonyl)oxy)methyl)-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

: 128781-07-7
5,6,7-trimethoxy-1H-indole-2-carboxylic acid

: 1333242-11-7
(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

Guidance literature:: tert-butyl 1-(((cyclohexylsulfonyl)oxy)methyl)-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate; With hydrogenchloride; In 1,4-dioxane; at 10 - 20 ℃;

5,6,7-trimethoxy-1H-indole-2-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 4837-38-1
cyclohexanesulfonyl chloride

: 1333242-11-7
(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 10 - 20 °C

2.2: 2 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 193225-63-7
3-(tert-butoxycarbonyl)-1-(hydroxymethyl)-5-nitro-1,2-dihydro-3H-benzindole

: 1333242-11-7
(5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl cyclohexanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 10 - 20 °C

2.2: 2 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2011.06.073