N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide

Base Information

• Chemical Name: N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide
• CAS No.: 209798-69-6
• Molecular Formula: C₁₇H₁₈F₃N₃O₄
• Molecular Weight: 385.343

Synonyms:N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide

Chemical Property of N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide

Chemical Property:

Purity/Quality:

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Technology Process of N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide

There total 4 articles about N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

7,7-bis(dimethylamino)-6,6-difluoro-1,3-dimethyl-5-(4'-fluorophenyl)-1,3,4,5,6,7-hexahydro-2H-pyrano[2,3-d]pyrimidine-2,4-dione (209798-65-2) → N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide (209798-69-6)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1016/S0040-4020(98)00329-9

Reference yield:

1,3-dimethylbarbituric acid (769-42-6) → N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide (209798-69-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / aq. ethanol / Heating

2: 90 percent / hexane; dimethylformamide / 20 °C

3: 86 percent / conc. HCl / CH₂Cl₂ / 0.17 h / 20 °C

With hydrogenchloride; In ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: hetero-Diels-Alder reaction / 3: Hydrolysis;

DOI:10.1016/S0040-4020(98)00329-9

Reference yield:

4-fluorobenzaldehyde (459-57-4) → N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide (209798-69-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / aq. ethanol / Heating

2: 90 percent / hexane; dimethylformamide / 20 °C

3: 86 percent / conc. HCl / CH₂Cl₂ / 0.17 h / 20 °C

With hydrogenchloride; In ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: hetero-Diels-Alder reaction / 3: Hydrolysis;

DOI:10.1016/S0040-4020(98)00329-9

upstream raw materials:

7,7-bis(dimethylamino)-6,6-difluoro-1,3-dimethyl-5-(4'-fluorophenyl)-1,3,4,5,6,7-hexahydro-2H-pyrano[2,3-d]pyrimidine-2,4-dione

1,3-dimethylbarbituric acid

4-fluorobenzaldehyde

5-(4-fluorobenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione

Downstream raw materials:

3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanoic acid

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