3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanoic acid

Base Information

• Chemical Name: 3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanoic acid
• CAS No.: 209798-73-2
• Molecular Formula: C₁₅H₁₃F₃N₂O₅
• Molecular Weight: 358.274

Synonyms:3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanoic acid

Chemical Property of 3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanoic acid

Chemical Property:

Purity/Quality:

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Technology Process of 3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanoic acid

There total 5 articles about 3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide (209798-69-6) → 3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanoic acid (209798-73-2)

Guidance literature:

With hydrogenchloride; In dichloromethane; for 2h; Heating;

DOI:10.1016/S0040-4020(98)00329-9

Reference yield:

1,3-dimethylbarbituric acid (769-42-6) → 3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanoic acid (209798-73-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / aq. ethanol / Heating

2: 90 percent / hexane; dimethylformamide / 20 °C

3: 86 percent / conc. HCl / CH₂Cl₂ / 0.17 h / 20 °C

4: 86 percent / conc. HCl / CH₂Cl₂ / 2 h / Heating

With hydrogenchloride; In ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: hetero-Diels-Alder reaction / 3: Hydrolysis / 4: Hydrolysis;

DOI:10.1016/S0040-4020(98)00329-9

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanoic acid (209798-73-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / aq. ethanol / Heating

2: 90 percent / hexane; dimethylformamide / 20 °C

3: 86 percent / conc. HCl / CH₂Cl₂ / 0.17 h / 20 °C

4: 86 percent / conc. HCl / CH₂Cl₂ / 2 h / Heating

With hydrogenchloride; In ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: hetero-Diels-Alder reaction / 3: Hydrolysis / 4: Hydrolysis;

DOI:10.1016/S0040-4020(98)00329-9

upstream raw materials:

N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-fluorophenyl)propanamide

1,3-dimethylbarbituric acid

4-fluorobenzaldehyde

5-(4-fluorobenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione

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