(+)-2-(trimethylsilyl)ethyl (1S)-1-acetamido-2,2-difluorocyclohexane-1-carboxylate

Base Information

Chemical Name:(+)-2-(trimethylsilyl)ethyl (1S)-1-acetamido-2,2-difluorocyclohexane-1-carboxylate
CAS No.:911395-60-3
Molecular Formula:C₁₄H₂₅F₂NO₃Si
Molecular Weight:321.44
Hs Code.:

Synonyms:(+)-2-(trimethylsilyl)ethyl (1S)-1-acetamido-2,2-difluorocyclohexane-1-carboxylate

Suppliers and Price of (+)-2-(trimethylsilyl)ethyl (1S)-1-acetamido-2,2-difluorocyclohexane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+)-2-(trimethylsilyl)ethyl (1S)-1-acetamido-2,2-difluorocyclohexane-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+)-2-(trimethylsilyl)ethyl (1S)-1-acetamido-2,2-difluorocyclohexane-1-carboxylate

There total 4 articles about (+)-2-(trimethylsilyl)ethyl (1S)-1-acetamido-2,2-difluorocyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 911395-59-0
(-)-2-(trimethylsilyl)ethyl (1S)-1-amino-2,2-difluorocyclohexane-1-carboxylate

: 108-24-7
acetic anhydride

: 911395-60-3
(+)-2-(trimethylsilyl)ethyl (1S)-1-acetamido-2,2-difluorocyclohexane-1-carboxylate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/ol061733c

Reference yield:

: (-)-2-(trimethylsilyl)ethyl 3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]imino}-5-hexenoate

: 911395-60-3
(+)-2-(trimethylsilyl)ethyl (1S)-1-acetamido-2,2-difluorocyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Zn / tetrahydrofuran / 0.67 h / 50 °C

1.2: 95 percent / tetrahydrofuran / 0.17 h / -40 °C

2.1: 92 percent / Grubbs reagent / CH₂Cl₂ / Heating

3.1: 98 percent / H₂ / Pd(OH)2/C / ethanol / 760 Torr

4.1: 68 percent / Et₃N; DMAP / tetrahydrofuran / 24 h / 20 °C

With dmap; Grubbs catalyst first generation; hydrogen; triethylamine; zinc; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol061733c

Reference yield:

: 911395-53-4
(-)-2-(trimethylsilyl)ethyl (1S)-6,6-difluoro-1-{[(1R)-1-phenyl-2-methoxyethyl]amino}-3-cyclohexene-1-carboxylate

: 911395-60-3
(+)-2-(trimethylsilyl)ethyl (1S)-1-acetamido-2,2-difluorocyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / H₂ / Pd(OH)2/C / ethanol / 760 Torr

2: 68 percent / Et₃N; DMAP / tetrahydrofuran / 24 h / 20 °C

With dmap; hydrogen; triethylamine; palladium dihydroxide; In tetrahydrofuran; ethanol;
DOI:10.1021/ol061733c