(-)-2-(trimethylsilyl)ethyl (1S)-1-amino-2,2-difluorocyclohexane-1-carboxylate

Base Information

Chemical Name:(-)-2-(trimethylsilyl)ethyl (1S)-1-amino-2,2-difluorocyclohexane-1-carboxylate
CAS No.:911395-59-0
Molecular Formula:C₁₂H₂₃F₂NO₂Si
Molecular Weight:279.402
Hs Code.:

Synonyms:(-)-2-(trimethylsilyl)ethyl (1S)-1-amino-2,2-difluorocyclohexane-1-carboxylate

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Chemical Property of (-)-2-(trimethylsilyl)ethyl (1S)-1-amino-2,2-difluorocyclohexane-1-carboxylate

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Technology Process of (-)-2-(trimethylsilyl)ethyl (1S)-1-amino-2,2-difluorocyclohexane-1-carboxylate

There total 4 articles about (-)-2-(trimethylsilyl)ethyl (1S)-1-amino-2,2-difluorocyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 911395-53-4
(-)-2-(trimethylsilyl)ethyl (1S)-6,6-difluoro-1-{[(1R)-1-phenyl-2-methoxyethyl]amino}-3-cyclohexene-1-carboxylate

: 911395-59-0
(-)-2-(trimethylsilyl)ethyl (1S)-1-amino-2,2-difluorocyclohexane-1-carboxylate

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; under 760 Torr;
DOI:10.1021/ol061733c

Reference yield: 98.0%

: 1309655-30-8
C₂₁H₃₁F₂NO₃Si

: 911395-59-0
(-)-2-(trimethylsilyl)ethyl (1S)-1-amino-2,2-difluorocyclohexane-1-carboxylate

Guidance literature:: With Pd(OH)2 (10% on C); hydrogen; In ethanol; under 760.051 Torr; Inert atmosphere;
DOI:10.1002/chem.201100113

Reference yield:

: (-)-2-(trimethylsilyl)ethyl 3,3-difluoro-2-{[(1R)-1-phenyl-2-methoxyethyl]imino}-5-hexenoate

: 911395-59-0
(-)-2-(trimethylsilyl)ethyl (1S)-1-amino-2,2-difluorocyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Zn / tetrahydrofuran / 0.67 h / 50 °C

1.2: 95 percent / tetrahydrofuran / 0.17 h / -40 °C

2.1: 92 percent / Grubbs reagent / CH₂Cl₂ / Heating

3.1: 98 percent / H₂ / Pd(OH)2/C / ethanol / 760 Torr

With Grubbs catalyst first generation; hydrogen; zinc; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol061733c