methanesulfonic acid trans-(3R,6S)-6-benzhydryl-tetrahydropyran-3-yl ester

Base Information

• Chemical Name: methanesulfonic acid trans-(3R,6S)-6-benzhydryl-tetrahydropyran-3-yl ester
• CAS No.: 869114-36-3
• Molecular Formula: C₁₉H₂₂O₄S
• Molecular Weight: 346.447
• Mol file: 869114-36-3.mol

Synonyms:methanesulfonic acid trans-(3R,6S)-6-benzhydryl-tetrahydropyran-3-yl ester

Chemical Property of methanesulfonic acid trans-(3R,6S)-6-benzhydryl-tetrahydropyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid trans-(3R,6S)-6-benzhydryl-tetrahydropyran-3-yl ester

There total 3 articles about methanesulfonic acid trans-(3R,6S)-6-benzhydryl-tetrahydropyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

→ methanesulfonic acid trans-(3R,6S)-6-benzhydryl-tetrahydropyran-3-yl ester (869114-36-3)

Guidance literature:

Reference yield: 74.7%

(S)-6-benzhydryltetrahydro-2H-pyran-3-ol + methanesulfonyl chloride (124-63-0) → methanesulfonic acid trans-(3R,6S)-6-benzhydryl-tetrahydropyran-3-yl ester (869114-36-3) + (3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl methanesulfonate (1289557-11-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm200020a

Reference yield:

(1S,4S,6R)-4-benzhydryl-3,7-dioxabicyclo[4.1.0]heptane (862647-18-5) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid trans-(3R,6S)-6-benzhydryl-tetrahydropyran-3-yl ester (869114-36-3) + Methanesulfonic acid (2S,4S)-2-benzhydryl-tetrahydro-pyran-4-yl ester

Guidance literature:

(1S,4S,6R)-4-benzhydryl-3,7-dioxabicyclo[4.1.0]heptane; With lithium aluminium tetrahydride; In diethyl ether; hexane; at 20 ℃; for 20h;

methanesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm0601699

upstream raw materials:

(1S,4S,6R)-4-benzhydryl-3,7-dioxabicyclo[4.1.0]heptane

methanesulfonyl chloride

Downstream raw materials:

(R)-2-((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-ylamino)-1-phenylethanol

(S)-2-((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-ylamino)-1-phenylethanol

(R)-2-(((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)-1-(4-fluorophenyl)ethanol

(S)-2-(((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)-1-(4-fluorophenyl)ethanol