(R)-2-(5-amino-4-cyclohexenyl-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-benzyl formate

Base Information

• Chemical Name: (R)-2-(5-amino-4-cyclohexenyl-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-benzyl formate
• CAS No.: 1350723-66-8
• Molecular Formula: C₂₂H₂₈N₄O₂
• Molecular Weight: 380.49
• Mol file: 1350723-66-8.mol

Synonyms:(R)-2-(5-amino-4-cyclohexenyl-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-benzyl formate

Chemical Property of (R)-2-(5-amino-4-cyclohexenyl-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-benzyl formate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(5-amino-4-cyclohexenyl-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-benzyl formate

There total 5 articles about (R)-2-(5-amino-4-cyclohexenyl-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-benzyl formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.1%

(R)-2-(5-amino-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-benzyl formate (1350723-65-7) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → (R)-2-(5-amino-4-cyclohexenyl-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-benzyl formate (1350723-66-8)

Guidance literature:

With acetic acid; at 50 - 60 ℃; Inert atmosphere;

Reference yield:

methyl (2R)-(benzyloxycarbonyl)pyrrolidine-2-carboxylate (182210-00-0) → (R)-2-(5-amino-4-cyclohexenyl-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-benzyl formate (1350723-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C

2.1: ethanol / 3 h / Inert atmosphere; Reflux

3.1: acetic acid / 50 - 60 °C / Inert atmosphere

With n-butyllithium; acetic acid; In tetrahydrofuran; ethanol;

Reference yield:

Z-D-proline (6404-31-5) → (R)-2-(5-amino-4-cyclohexenyl-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-benzyl formate (1350723-66-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / benzene / 3 h / 20 °C

2.1: benzene / 1 h

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C

4.1: ethanol / 3 h / Inert atmosphere; Reflux

5.1: acetic acid / 50 - 60 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; benzene;

upstream raw materials:

Z-D-proline

N-benzyloxycarbonyl-D-proline acid chloride

methyl (2R)-(benzyloxycarbonyl)pyrrolidine-2-carboxylate

(R)-2-(2-cyanoacetyl)pyrrolidine-1-benzyl formate