1-[5-(tert-butyldimethylsilanyloxymethyl)tetrahydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[5-(tert-butyldimethylsilanyloxymethyl)tetrahydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione
CAS No.:1380572-79-1
Molecular Formula:C₃₀H₃₅Cl₅N₂O₆Si
Molecular Weight:724.968
Hs Code.:

1-[5-(tert-butyldimethylsilanyloxymethyl)tetrahydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione

Synonyms:1-[5-(tert-butyldimethylsilanyloxymethyl)tetrahydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[5-(tert-butyldimethylsilanyloxymethyl)tetrahydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-[5-(tert-butyldimethylsilanyloxymethyl)tetrahydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione

There total 6 articles about 1-[5-(tert-butyldimethylsilanyloxymethyl)tetrahydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1380572-78-0
1-[5-(tert-butyldimethylsilanyloxymethyl)-2,5-dihydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione

: 1380572-79-1
1-[5-(tert-butyldimethylsilanyloxymethyl)tetrahydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In water; isopropyl alcohol; for 2h; chemoselective reaction;
DOI:10.1016/j.tet.2012.03.121

Reference yield:

: 1380572-77-9
O,O'-((2R,3R,4R,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(3-(((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl) S,S'-dimethyl dicarbonodithioate

: 1380572-79-1
1-[5-(tert-butyldimethylsilanyloxymethyl)tetrahydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 0.5 h / 100 °C

2: palladium 10% on activated carbon; hydrogen / water; isopropyl alcohol / 2 h

With 2,2'-azobis(isobutyronitrile); palladium 10% on activated carbon; hydrogen; tri-n-butyl-tin hydride; In water; isopropyl alcohol; toluene;
DOI:10.1016/j.tet.2012.03.121

Reference yield:

: 1380572-64-4
(2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methanone

: 1380572-79-1
1-[5-(tert-butyldimethylsilanyloxymethyl)tetrahydrofuran-2-yl]-3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

2.2: 3 h / 0 °C

3.1: sulfuryl dichloride / dichloromethane / 1 h / 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0 °C

5.1: 1H-imidazole / dichloromethane / 4 h

6.1: sodium hydroxide / dimethyl sulfoxide / 0.33 h

6.2: 0.5 h

6.3: 2 h

7.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 0.5 h / 100 °C

8.1: palladium 10% on activated carbon; hydrogen / water; isopropyl alcohol / 2 h

With 1H-imidazole; lithium borohydride; sulfuryl dichloride; 2,2'-azobis(isobutyronitrile); palladium 10% on activated carbon; hydrogen; tri-n-butyl-tin hydride; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; toluene; mineral oil;
DOI:10.1016/j.tet.2012.03.121