6-amino-4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxyquinoline

Base Information

• Chemical Name: 6-amino-4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxyquinoline
• CAS No.: 362050-91-7
• Molecular Formula: C₂₂H₂₅N₃O₄
• Molecular Weight: 395.458
• Mol file: 362050-91-7.mol

Synonyms:6-amino-4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxyquinoline

Chemical Property of 6-amino-4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxyquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-amino-4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxyquinoline

There total 5 articles about 6-amino-4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxy-6-nitroquinoline (362050-90-6) → 6-amino-4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxyquinoline (362050-91-7)

Guidance literature:

With cyclohexene; palladium on activated charcoal; In ethanol; for 0.75h; Heating;

DOI:10.1016/S0968-0896(01)00078-5

Reference yield:

tributyl (o-tert-butyloxycarbonylaminophenyl) stannane (148493-54-3) → 6-amino-4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxyquinoline (362050-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / PdCl₂(CH₃CN)2 / dioxane / 14 h / 55 °C

2: 100 percent / cyclohexene / 10 percent Pd/C / ethanol / 0.75 h / Heating

With cyclohexene; dichloro bis(acetonitrile) palladium(II); palladium on activated charcoal; In 1,4-dioxane; ethanol;

DOI:10.1016/S0968-0896(01)00078-5

Reference yield:

4-bromo-5,8-dimethoxy-6-nitroquinoline (362050-89-3) → 6-amino-4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxyquinoline (362050-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / PdCl₂(CH₃CN)2 / dioxane / 14 h / 55 °C

2: 100 percent / cyclohexene / 10 percent Pd/C / ethanol / 0.75 h / Heating

With cyclohexene; dichloro bis(acetonitrile) palladium(II); palladium on activated charcoal; In 1,4-dioxane; ethanol;

DOI:10.1016/S0968-0896(01)00078-5

upstream raw materials:

4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxy-6-nitroquinoline

tributyl (o-tert-butyloxycarbonylaminophenyl) stannane

4-bromo-5,8-dimethoxy-6-nitroquinoline

5,8-dimethoxy-6-nitro-4-(trifluoromethanesulfonyloxy)quinoline

Downstream raw materials:

N-(2-{6-[(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-5,8-dimethoxy-quinolin-4-yl}-phenyl)-2,2,2-trifluoro-acetamide

4-(2-tert-butyloxycarbonylaminophenyl)-6-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethylamino)-5,8-dimethoxyquinoline