4-(2-tert-butyloxycarbonylaminophenyl)-6-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethylamino)-5,8-dimethoxyquinoline

Base Information

Chemical Name:4-(2-tert-butyloxycarbonylaminophenyl)-6-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethylamino)-5,8-dimethoxyquinoline
CAS No.:362050-92-8
Molecular Formula:C₂₉H₃₁N₃O₈
Molecular Weight:549.58
Hs Code.:

Synonyms:4-(2-tert-butyloxycarbonylaminophenyl)-6-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethylamino)-5,8-dimethoxyquinoline

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Chemical Property of 4-(2-tert-butyloxycarbonylaminophenyl)-6-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethylamino)-5,8-dimethoxyquinoline

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Technology Process of 4-(2-tert-butyloxycarbonylaminophenyl)-6-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethylamino)-5,8-dimethoxyquinoline

There total 6 articles about 4-(2-tert-butyloxycarbonylaminophenyl)-6-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethylamino)-5,8-dimethoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2033-24-1
cycl-isopropylidene malonate

: 122-51-0
orthoformic acid triethyl ester

: 362050-91-7
6-amino-4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxyquinoline

: 362050-92-8
4-(2-tert-butyloxycarbonylaminophenyl)-6-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethylamino)-5,8-dimethoxyquinoline

Guidance literature:: cycl-isopropylidene malonate; orthoformic acid triethyl ester; for 2h; Heating;

6-amino-4-(2-tert-butyloxycarbonylaminophenyl)-5,8-dimethoxyquinoline; for 4h; Heating;
DOI:10.1016/S0968-0896(01)00078-5

Reference yield:

: 148493-54-3
tributyl (o-tert-butyloxycarbonylaminophenyl) stannane

: 362050-92-8
4-(2-tert-butyloxycarbonylaminophenyl)-6-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethylamino)-5,8-dimethoxyquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / PdCl₂(CH₃CN)2 / dioxane / 14 h / 55 °C

2.1: 100 percent / cyclohexene / 10 percent Pd/C / ethanol / 0.75 h / Heating

3.1: 2 h / Heating

3.2: 72 percent / 4 h / Heating

With cyclohexene; dichloro bis(acetonitrile) palladium(II); palladium on activated charcoal; In 1,4-dioxane; ethanol;
DOI:10.1016/S0968-0896(01)00078-5

Reference yield:

: 5,8-dimethoxy-6-nitro-4(1H)-quinolone

: 362050-92-8
4-(2-tert-butyloxycarbonylaminophenyl)-6-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethylamino)-5,8-dimethoxyquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: 76 percent / DMAP; 2,6-lutidine / CH₂Cl₂ / 20 h / 20 °C

2.1: 100 percent / LiBr / dioxane / 2 h / Heating

3.1: 100 percent / PdCl₂(CH₃CN)2 / dioxane / 14 h / 55 °C

4.1: 100 percent / cyclohexene / 10 percent Pd/C / ethanol / 0.75 h / Heating

5.1: 2 h / Heating

5.2: 72 percent / 4 h / Heating

With 2,6-dimethylpyridine; dmap; lithium bromide; cyclohexene; dichloro bis(acetonitrile) palladium(II); palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/S0968-0896(01)00078-5