Technology Process of tert-butyl (4-(benzyloxy)-5-bromo-1-iodonaphthalen-2-yl)-(3-chloroallyl)carbamate
There total 4 articles about tert-butyl (4-(benzyloxy)-5-bromo-1-iodonaphthalen-2-yl)-(3-chloroallyl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl (4-(benzyloxy)-5-bromo-1-iodonaphthalen-2-yl)carbamate;
With
tetra-(n-butyl)ammonium iodide; sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.5h;
E/Z-1,3-Dichloropropene;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 1h;
DOI:10.1021/jm300330b
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 24 h / 25 °C
2.1: diphenyl phosphoryl azide; triethylamine / 14 h / 85 °C / Inert atmosphere
3.1: N-iodo-succinimide; toluene-4-sulfonic acid / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere; Darkness
4.1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
4.2: 1 h / 20 °C
With
N-iodo-succinimide; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm300330b
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / ethanol / 1 h / 80 °C
2.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C
3.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 24 h / 25 °C
4.1: diphenyl phosphoryl azide; triethylamine / 14 h / 85 °C / Inert atmosphere
5.1: N-iodo-succinimide; toluene-4-sulfonic acid / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere; Darkness
6.1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
6.2: 1 h / 20 °C
With
N-iodo-succinimide; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm300330b
