Technology Process of tert-butyl 1,2-dihydro-5-(benzyloxy)-6-bromo-1-(chloromethyl)-1H-benzo[e]indole-3(2H)-carboxylate
There total 5 articles about tert-butyl 1,2-dihydro-5-(benzyloxy)-6-bromo-1-(chloromethyl)-1H-benzo[e]indole-3(2H)-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
benzene;
at 80 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/jm300330b
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 24 h / 25 °C
2.1: diphenyl phosphoryl azide; triethylamine / 14 h / 85 °C / Inert atmosphere
3.1: N-iodo-succinimide; toluene-4-sulfonic acid / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere; Darkness
4.1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
4.2: 1 h / 20 °C
5.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / 12 h / 80 °C / Inert atmosphere
With
N-iodo-succinimide; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); diphenyl phosphoryl azide; water; tri-n-butyl-tin hydride; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.1021/jm300330b
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / ethanol / 1 h / 80 °C
2.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C
3.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 24 h / 25 °C
4.1: diphenyl phosphoryl azide; triethylamine / 14 h / 85 °C / Inert atmosphere
5.1: N-iodo-succinimide; toluene-4-sulfonic acid / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere; Darkness
6.1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
6.2: 1 h / 20 °C
7.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / 12 h / 80 °C / Inert atmosphere
With
N-iodo-succinimide; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); diphenyl phosphoryl azide; water; tri-n-butyl-tin hydride; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.1021/jm300330b
