1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethanamine

Base Information

Chemical Name:1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethanamine
CAS No.:1312605-73-4
Molecular Formula:C₁₆H₁₄FN₃
Molecular Weight:267.306
Hs Code.:

Synonyms:1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethanamine

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Chemical Property of 1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethanamine

Chemical Property:

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Technology Process of 1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethanamine

There total 12 articles about 1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312605-72-3
2-(1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethyl)-1H-isoindole-1,3 (2H)-dione

: 1312605-73-4
1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethanamine

Guidance literature:: With hydrazine hydrate; In ethanol; at 20 ℃; for 18h;

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 1312605-73-4
1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethanamine

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 48 h / 100 °C / Inert atmosphere

2: selenium(IV) oxide / 1,4-dioxane / 16 h / Reflux

3: toluene-4-sulfonic acid / toluene / 12 h / 120 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr

5: toluene-4-sulfonic acid / toluene / 4 h / 120 °C

6: diisobutylaluminium hydride / toluene; cyclohexane / 3 h / -78 - 0 °C

7: manganese(IV) oxide / 1,4-dioxane / 2 h / 20 °C

8: diethyl ether; tetrahydrofuran / 0 °C

9: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C

10: hydrazine hydrate / ethanol / 18 h / 20 °C

With manganese(IV) oxide; selenium(IV) oxide; di-isopropyl azodicarboxylate; hydrogen; diisobutylaluminium hydride; potassium carbonate; hydrazine hydrate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; cyclohexane; toluene;

Reference yield:

: 10261-94-6
3-nitropyridine-2-carboxaldehyde

: 1312605-73-4
1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethanamine

Guidance literature:: Multi-step reaction with 8 steps

1: toluene-4-sulfonic acid / toluene / 12 h / 120 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr

3: toluene-4-sulfonic acid / toluene / 4 h / 120 °C

4: diisobutylaluminium hydride / toluene; cyclohexane / 3 h / -78 - 0 °C

5: manganese(IV) oxide / 1,4-dioxane / 2 h / 20 °C

6: diethyl ether; tetrahydrofuran / 0 °C

7: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C

8: hydrazine hydrate / ethanol / 18 h / 20 °C

With manganese(IV) oxide; di-isopropyl azodicarboxylate; hydrogen; diisobutylaluminium hydride; hydrazine hydrate; triphenylphosphine; palladium 10% on activated carbon; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; cyclohexane; toluene;