2-Methyl-3-nitropyridine

Base Information

• Chemical Name: 2-Methyl-3-nitropyridine
• CAS No.: 18699-87-1
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.126
• Hs Code.: 2933399090
• Mol file: 18699-87-1.mol

Synonyms:3-Nitro-2-methylpyridine;3-Nitro-2-picoline;NSC 311455;2-Picoline,3-nitro- (7CI,8CI);2-Methyl-3-nitropyridine;

Chemical Property of 2-Methyl-3-nitropyridine

Chemical Property:

• Appearance/Colour: beige moist crystals
• Vapor Pressure: 0.235mmHg at 25°C
• Melting Point: 32-33 °C
• Refractive Index: 1.558
• Boiling Point: 213.8 °C at 760 mmHg
• PKA: 1.92±0.10(Predicted)
• Flash Point: 83.1 °C
• PSA: 58.71000
• Density: 1.246 g/cm³
• LogP: 1.82140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methyl-3-nitropyridine is used as a starting reagent to synthesize 3-substituted-4 or 6-azaindoles, and is also used as a reagent to prepare 3-azaindolyl-4-arylmalemides (compounds that exhibit antiproliferative activity).

Technology Process of 2-Methyl-3-nitropyridine

There total 28 articles about 2-Methyl-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

dimethyl 2-(3-nitropyridin-2-yl)malonate (173417-34-0) → 2-methyl-3-nitropyridine (18699-87-1)

Guidance literature:

dimethyl 2-(3-nitropyridin-2-yl)malonate; With hydrogenchloride; In water; for 8h; Reflux;

With sodium carbonate; In water;

Reference yield: 90.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + dihydroxy-methyl-borane (13061-96-6) → 2-methyl-3-nitropyridine (18699-87-1)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; for 48h; Heating;

DOI:10.1016/S0040-4020(98)00328-7

Reference yield: 86.0%

diethyl 2-(3-nitropyridin-2-yl)malonate (64362-41-0) → 2-methyl-3-nitropyridine (18699-87-1)

Guidance literature:

With hydrogenchloride; for 8h; Heating;

DOI:10.1039/b506652b

upstream raw materials:

2-methyl-3-pyridinamine

6-chloro-4-methyl-3-nitropyridine

acetic anhydride

aniline

Downstream raw materials:

3-nitropyridine-2-carboxylic acid

2-(3-nitro-2-pyridinyl)-N,N-dimethyletheneamine

2-methyl-3-pyridinamine

2-methyl-3-nitropyridine 1-oxide

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