(R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea

Base Information

Chemical Name:(R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea
CAS No.:1384984-18-2
Molecular Formula:C₂₁H₂₅FN₆O₃
Molecular Weight:428.466
Hs Code.:
Mol file:1384984-18-2.mol

Synonyms:(+)-(R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea

Suppliers and Price of (R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
VXc-486 >98%
100 mg
$ 1200.00

DC Chemicals
VXc-486 >98%
250 mg
$ 2100.00

ChemScene
SPR719 99.04%
100mg
$ 3500.00

ChemScene
SPR719 99.04%
50mg
$ 2400.00

ChemScene
SPR719 99.04%
25mg
$ 1550.00

ChemScene
SPR719 99.04%
10mg
$ 800.00

ChemScene
SPR719 99.04%
5mg
$ 480.00

Total 9 raw suppliers

Chemical Property of (R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea

Chemical Property:

PKA:8.31±0.30(Predicted)
Density:1.374±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

VXc-486 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea

There total 14 articles about (R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1384984-17-1
1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea

: 1384984-18-2
(+)-(R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea

Guidance literature:: With triethylamine; In methanol; dichloromethane; at 25 ℃; Purification / work up; Resolution of racemate;

Reference yield: 40.0%

: 1384984-17-1
1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea

: 1384984-18-2
(+)-(R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea

: (-)-(S)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)-pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)-urea

Guidance literature:: With 2,2'-iminobis[ethanol]; In methanol; at 35 ℃; under 75007.5 Torr;
DOI:10.1021/jm500563g

Reference yield:

: 59255-94-6
2-bromo-3-fluoronitrobenzene

: 1384984-18-2
(+)-(R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I) / 1,4-dioxane / 2 h / Reflux

1.2: 2327.23 Torr / Inert atmosphere

2.1: N-Bromosuccinimide / acetonitrile; tert-butyl methyl ether / 1 h / -20 - -10 °C

3.1: tetrahydrofuran / 2 - 35 °C

3.2: 2.67 h / 30 - 41 °C

4.1: water; sulfuric acid / 1,4-dioxane / 120 h / Reflux

5.1: sodium hydrogencarbonate / 1,4-dioxane; water / 2 h / Inert atmosphere

5.2: Reflux

6.1: triethylamine; hydrogen / 5%-palladium/activated carbon / water; tetrahydrofuran; methanol / 2327.23 Torr / Inert atmosphere

7.1: sodium acetate; sulfuric acid / 1,4-dioxane; water / pH 3.5 / Reflux

7.2: 0.5 h / 20 °C / pH 8 - 9

8.1: triethylamine / dichloromethane; methanol / 25 °C / Resolution of racemate

With N-Bromosuccinimide; sulfuric acid; water; hydrogen; sodium acetate; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I); 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; tert-butyl methyl ether; water; acetonitrile; 1.1: Heck coupling / 5.1: Suzuki Coupling;