(R)-dibenzyl 2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl phosphate

Base Information

Chemical Name:(R)-dibenzyl 2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl phosphate
CAS No.:1384984-30-8
Molecular Formula:C₃₅H₃₈FN₆O₆P
Molecular Weight:688.695
Hs Code.:

Synonyms:(R)-dibenzyl 2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl phosphate

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Chemical Property of (R)-dibenzyl 2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl phosphate

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Technology Process of (R)-dibenzyl 2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl phosphate

There total 9 articles about (R)-dibenzyl 2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.27%

: C₃₈H₄₂FN₆O₈P

: 1384984-30-8
(R)-dibenzyl 2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl phosphate

Guidance literature:: C₃₈H₄₂FN₆O₈P; With trifluoroacetic acid; In dichloromethane; water; at 23 ℃; for 3.5h;

With methanol; In dichloromethane; water; for 18h;

Reference yield: 85.27%

: 1384984-18-2
(+)-(R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1384984-30-8
(R)-dibenzyl 2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl phosphate

Guidance literature:: (+)-(R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In N,N-dimethyl-formamide; acetonitrile; at 23 ℃; for 20.5h; Inert atmosphere;

With 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide; acetonitrile; at 0 - 23 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; Product distribution / selectivity;