1-N-(tert-butoxycarbonyl)-3-<4-(N,N-dimethylcarboxamido)-4-phenylpiperidin-1-yl>propylamine

Base Information

Chemical Name:1-N-(tert-butoxycarbonyl)-3-<4-(N,N-dimethylcarboxamido)-4-phenylpiperidin-1-yl>propylamine
CAS No.:219553-45-4
Molecular Formula:C₂₂H₃₅N₃O₃
Molecular Weight:389.538
Hs Code.:

Synonyms:1-N-(tert-butoxycarbonyl)-3-<4-(N,N-dimethylcarboxamido)-4-phenylpiperidin-1-yl>propylamine

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Chemical Property of 1-N-(tert-butoxycarbonyl)-3-<4-(N,N-dimethylcarboxamido)-4-phenylpiperidin-1-yl>propylamine

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Technology Process of 1-N-(tert-butoxycarbonyl)-3-<4-(N,N-dimethylcarboxamido)-4-phenylpiperidin-1-yl>propylamine

There total 6 articles about 1-N-(tert-butoxycarbonyl)-3-<4-(N,N-dimethylcarboxamido)-4-phenylpiperidin-1-yl>propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 506-59-2
N,N-dimethylammonium chloride

: 219553-44-3
1-<3-(N-tert-butoxycarbonylamino)propyl>-4-phenylpiperidine-4-carboxylic acid

: 219553-45-4
1-N-(tert-butoxycarbonyl)-3-<4-(N,N-dimethylcarboxamido)-4-phenylpiperidin-1-yl>propylamine

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; for 24h; Ambient temperature;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 219553-45-4
1-N-(tert-butoxycarbonyl)-3-<4-(N,N-dimethylcarboxamido)-4-phenylpiperidin-1-yl>propylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / 1 N aq. NaOH / dioxane / 12 h / 0 - 20 °C

2: 76 percent / EDC, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; sodium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 77-17-8
Normeperidine

: 219553-45-4
1-N-(tert-butoxycarbonyl)-3-<4-(N,N-dimethylcarboxamido)-4-phenylpiperidin-1-yl>propylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 83.3 percent / K₂CO₃, KI / dioxane / 24 h / Heating

2: 99 percent / 6 N aq. HCl / 3 h / Heating

3: 83 percent / 1 N aq. NaOH / dioxane / 12 h / 0 - 20 °C

4: 76 percent / EDC, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

With hydrogenchloride; dmap; sodium hydroxide; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; potassium iodide; In 1,4-dioxane; dichloromethane;