10-(4-chloro-benzyl)-2,10-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazine-3,4-dione

Base Information

• Chemical Name: 10-(4-chloro-benzyl)-2,10-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazine-3,4-dione
• CAS No.: 388575-00-6
• Molecular Formula: C₁₆H₁₁ClN₄O₂
• Molecular Weight: 326.742

Synonyms:10-(4-chloro-benzyl)-2,10-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazine-3,4-dione

Chemical Property of 10-(4-chloro-benzyl)-2,10-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazine-3,4-dione

Chemical Property:

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Technology Process of 10-(4-chloro-benzyl)-2,10-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazine-3,4-dione

There total 2 articles about 10-(4-chloro-benzyl)-2,10-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazine-3,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

oxalic acid diethyl ester (95-92-1) + [1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-hydrazine (388574-82-1) → 10-(4-chloro-benzyl)-2,10-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazine-3,4-dione (388575-00-6)

Guidance literature:

In ethanol; Heating;

DOI:10.1021/jm0109210

Reference yield:

2-Chloro-1-(p-chlorophenylmethyl)-1H-benzimidazole (131705-80-1) → 10-(4-chloro-benzyl)-2,10-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazine-3,4-dione (388575-00-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / hydrazine hydrate / 5 h / 160 °C

2: 42 percent / ethanol / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1021/jm0109210

Reference yield: 73.0%

ethyl bromoacetate (105-36-2) + 10-(4-chloro-benzyl)-2,10-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazine-3,4-dione (388575-00-6) → [10-(4-chloro-benzyl)-3,4-dioxo-3,4-dihydro-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-2-yl]-acetic acid ethyl ester (388575-15-3)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1021/jm0109210

upstream raw materials:

oxalic acid diethyl ester

[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-hydrazine

2-Chloro-1-(p-chlorophenylmethyl)-1H-benzimidazole

Downstream raw materials:

[10-(4-chloro-benzyl)-3,4-dioxo-3,4-dihydro-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-2-yl]-acetic acid ethyl ester

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