ethyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Base Information

Chemical Name:ethyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate
CAS No.:1481640-53-2
Molecular Formula:C₂₀H₁₃ClF₄N₂O₅
Molecular Weight:472.78
Hs Code.:

Synonyms:ethyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

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Chemical Property of ethyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

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Technology Process of ethyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

There total 3 articles about ethyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1481640-51-0
ethyl 2-(2,4-dichloro-5-nitrobenzoyl)-3-{[2-fluoro-4-(trifluoromethyl)benzyl]amino}acrylate

: 1481640-53-2
ethyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1021/jm401362f

Reference yield:

: 148926-94-7
ethyl ester of 3-dimethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid

: 1481640-53-2
ethyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; diethyl ether / 0.08 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With potassium carbonate; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm401362f

Reference yield:

: 239087-05-9
2-fluoro-4-(trifluoromethyl)benzylamine

: 1481640-53-2
ethyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; diethyl ether / 0.08 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With potassium carbonate; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm401362f