2-methylbenzyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Base Information

Chemical Name:2-methylbenzyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate
CAS No.:1481640-57-6
Molecular Formula:C₂₆H₁₇ClF₄N₂O₅
Molecular Weight:548.878
Hs Code.:

Synonyms:2-methylbenzyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Suppliers and Price of 2-methylbenzyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-methylbenzyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-methylbenzyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

There total 5 articles about 2-methylbenzyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1481640-55-4
7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

: 552-45-4
1-chloromethyl-2-methylbenzene

: 1481640-57-6
2-methylbenzyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 24h;
DOI:10.1021/jm401362f

Reference yield:

: 148926-94-7
ethyl ester of 3-dimethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid

: 1481640-57-6
2-methylbenzyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol; diethyl ether / 0.08 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

3: hydrogenchloride / water / 2.17 h / 120 °C / 11251.1 Torr / Microwave irradiation

4: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C

With hydrogenchloride; potassium carbonate; In diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm401362f

Reference yield:

: 1481640-51-0
ethyl 2-(2,4-dichloro-5-nitrobenzoyl)-3-{[2-fluoro-4-(trifluoromethyl)benzyl]amino}acrylate

: 1481640-57-6
2-methylbenzyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

2: hydrogenchloride / water / 2.17 h / 120 °C / 11251.1 Torr / Microwave irradiation

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C

With hydrogenchloride; potassium carbonate; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm401362f