(2R,3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-3-naphthalen-2-yl-hexadecahydro-cyclopenta[a]phenanthren-2-ol

Base Information

Chemical Name:(2R,3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-3-naphthalen-2-yl-hexadecahydro-cyclopenta[a]phenanthren-2-ol
CAS No.:156177-48-9
Molecular Formula:C₃₇H₅₄O
Molecular Weight:514.835
Hs Code.:

Synonyms:(2R,3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-3-naphthalen-2-yl-hexadecahydro-cyclopenta[a]phenanthren-2-ol

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Chemical Property of (2R,3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-3-naphthalen-2-yl-hexadecahydro-cyclopenta[a]phenanthren-2-ol

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Technology Process of (2R,3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-3-naphthalen-2-yl-hexadecahydro-cyclopenta[a]phenanthren-2-ol

There total 2 articles about (2R,3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-3-naphthalen-2-yl-hexadecahydro-cyclopenta[a]phenanthren-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21473-01-8
2-naphthalenylmagnesium bromide

: 156177-48-9
(2R,3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-3-naphthalen-2-yl-hexadecahydro-cyclopenta[a]phenanthren-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran

2: SOCl₂ / pyridine / Ambient temperature

3: 1.) BH₃-Me₂S; 2.) H₂O₂, NaOH / 1.) THF, reflux; 2.) reflux

With sodium hydroxide; thionyl chloride; dimethylsulfide borane complex; dihydrogen peroxide; In tetrahydrofuran; pyridine;
DOI:10.1016/S0040-4039(00)75783-2

Reference yield:

: 156177-54-7
(R)-2-Hydroxy-2-phenyl-butyric acid (2R,3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-3-naphthalen-2-yl-hexadecahydro-cyclopenta[a]phenanthren-2-yl ester

: 3966-31-2
(R)-2-hydroxy-2-phenylbutyric acid

: 156177-48-9
(2R,3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-3-naphthalen-2-yl-hexadecahydro-cyclopenta[a]phenanthren-2-ol

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)75783-2

Reference yield:

: 156177-48-9
(2R,3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-3-naphthalen-2-yl-hexadecahydro-cyclopenta[a]phenanthren-2-ol

: 156177-54-7
(R)-2-Hydroxy-2-phenyl-butyric acid (2R,3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-3-naphthalen-2-yl-hexadecahydro-cyclopenta[a]phenanthren-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: p-toluenesulfone acid (PTSA) / benzene

2: tetrahydrofuran

With toluene-4-sulfonic acid; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(00)75783-2